胃康胶囊治疗胃癌前病变临床研究.docVIP

胃康胶囊治疗胃癌前病变临床研究 　　[摘要] 目的:探讨胃康胶囊对癌前期病变的治疗作用。方法:治疗组128例,硫糖铝对照组128例。全部病例均经胃镜和胃黏膜活组织病理检验确诊。治疗期间停服其他药物,2个月为1个疗程,连服2个疗程。结果:治疗组与对照组相比较,两组总有效率分别为70.31%、43.39%(P0.01);治疗组脾胃虚弱型与气阴两虚型总有效率分别为77.78%、44.37%(P0.01)。胃康胶囊能提高患者的血色素,细胞免疫功能和血浆cAMP含量,并有抑制幽门螺杆菌的作用。结论:胃康胶囊有治疗胃癌前期病变和预防胃癌发生的作用。 　　[关键词] 胃康胶囊;胃癌前病变;治疗 　　[中图分类号] R735.2 [文献标识码] A[文章编号]1673-7210(2010)03(a)-063-03 　　 　　Clinic study of Weikang Capsule in the treatment of precancerous lesion 　　LIU Peizhou, WANG Xingmin 　　(Yidu Health School of Shandong, Yidu 262500, China) 　　[Abstract] Objective: To investigate the effect of Weikang Capsule on precancerous lesion of stomach.Methods: 128 patients taking Weikang Capsules was theraputic group, 128 patients taking Sucrafate was contrast group. All patients were diagnosed by endoscope and pathology of gastric mucosa. Other medicines were not taken during the time of treatment. Two monthes was a treatment course, the medicines were taken for two courses. Results: The effective rate of the two groups was 70.31% and 43.39% in theraputic and contrast groups(P0.01). The effective rate of spleen and stomach weakness in theroputic group was 77.78%, and the effective rate of deficiency of Qi and Yin in theroputic group was 44.73%(P0.01). Weikang Capsule can made Hb, serum cAMP high, improve fanction of immune cells and inhibit Hp. Conclusion: WeiKang is effective in treatment of precancerous lesion and prevents gastric cancer. 　　[Key words]Weikang Capsule; Precancerous lesion; Treatment 　　 　　慢性萎缩性胃炎(CAG)、肠腺化生(IM)、不典型增生(ATP)是胃癌前病变。有资料表明,当CAG伴随IM和ATP时,其癌变率达4%~30%。积极治疗这类病变,对降低胃癌的发生有重要意义。许多学者从不同角度利用不同的方法进行研究,笔者用纯中药成分的胃康胶囊治疗胃癌前病变,取得了较满意的效果,现报道如下: 　　1 资料与方法 　　1.1一般资料 　　治疗组128例,男80例,女48例;年龄最小20岁,最大70岁,平均45.5岁。对照组128例,男82例,女46例;年龄最小25岁,最大68岁,平均45.8岁。 　　1.2 病程与病变程度 　　治疗组最短2个月,最长4年,平均2.5年;对照组最短2个月,最长4年,平均2.5年。按组织学分级:治疗组轻度50例(39.06%),中度以上78例(60.93%);对照组轻度60例(46.03%),中度以上68例(60.37%)。 　　1.3 病例选择 　　经电子胃镜检查及胃黏膜活组织检查确诊为CAG(轻、中、重)伴或IM、ATP(轻、中、重),并排除活动性病变者为研究对象。 　　1.4中医辨证分型 　　参照1993年全国胃炎会议关