肺炎支原体感染与小儿支气管哮喘发作关系探究.docVIP

肺炎支原体感染与小儿支气管哮喘发作关系探究 　　[摘要] 目的 研究并探讨肺炎支原体感染与小儿支气管哮喘发作的相关性。 方法 于2015年1月―2017年1月期间，方便选取该院收治的70例支气管哮喘急性发作期患儿和70例上呼吸道感染患儿设置为观察组、对照组，所有患儿均接受血清肺炎支原体抗体（MP-IgM）检测，统计两组MP-IgM阳性检出情况，再将观察组分为MP-IgM阳性组、阴性组，对其呼出气一氧化氮（FeNO）浓度、外周血嗜酸性粒细胞比例（EO）、血清特异性IgE进行检测。 结果 观察组的MP-IgM阳性率为45.71%，对照组为15.71%，经比较，观察组的MP-IgM阳性率高于对照组（P0.05）。阳性组的FeNO浓度、EO%、血清IgE水平均高于阴性组（P0.05）。相关性分析后发现，肺炎支原体感染与小儿支气管哮喘急性发作呈正相关。结论 肺炎支原体感染与小儿支气管哮喘急性发作密切相关，可能参与到小儿支气管哮喘发生、发展过程中。 　　[关键词] 儿科；支气管哮喘；肺炎支原体；相关性 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）11（b）-0034-03 　　[Abstract] Objective This paper tries to study and explore the correlation between mycoplasma pneumoniae infection and bronchial asthma in children. Methods From January 2015 to January 2017， 70 cases of children with acute bronchial asthma and 70 cases of children with upper respiratory tract infection who admitted in this hospital were convenient selected and regarded as the observation group and the control group. All the children were tested for serum mycoplasma pneumoniae antibody （MP-IgM）， the positive rate of MP-IgM in two groups was counted， and the observation group was divided into MP-IgM positive group and negative group， the levels of exhaled nitric oxide （FeNO）， peripheral blood eosinophils （EO） and serum specific IgE were examined. Results The positive rate of MP-IgM in the observation group was 45.71%， and that in the control group was 15.71%. The positive rate of MP-IgM in the observation group was higher than that in the control group （P0.05）. The concentration of FeNO， EO% and serum IgE in the positive group were higher than those of the negative group （P0.05）. Correlation analysis showed that mycoplasma pneumoniae infection was positively related to acute attack of bronchial asthma in children. Conclusion Mycoplasma pneumoniae infection is closely related to acute attack of bronchial asthma in children and may be involved in the occurrence and development of bronchial asthma in children. 　　[Key words] Pediatric； Bronchial asthma； Mycoplas