肿瘤标志物在左右半大肠腺癌中研究价值及意义.docVIP

肿瘤标志物在左右半大肠腺癌中研究价值及意义 　　[摘要] 目的 探讨肿瘤标志物癌胚抗原（CEA）、CA125、CA724、CA199在左右半大肠腺癌诊断中的应用价值及意义。 方法 回顾分析2015年7月～2016年7月在武汉大学人民医院经病理确诊的162例大肠腺癌患者，其中左半大肠腺癌97例，右半大肠腺癌65例，收集患者的血清肿瘤标志物及临床病理参数资料，比较分析左、右半大肠腺癌的差异。 结果 97例左半大肠腺癌患者中CEA、CA125、CA724、CA199的?性率分别为38.1%、25.8%、62.9%、30.9%，4种标志物联合检测的阳性率为59.8%；65例右半大肠腺癌患者中CEA、CA125、CA724、CA199的阳性率分别为53.8%、23.0%、46.2%、40.0%，4种标志物联合检测的阳性率为64.6%。左半大肠腺癌神经侵犯患者CA125的阳性率、右半大肠腺癌神经侵犯者CA199的阳性率、左右半大肠腺癌脉管侵犯CA199的阳性率与未发生神经侵犯者比较，差异均有统计学意义（P 0.05）。 结论 肿瘤标记CEA、CA125、CA724、CA199在左右半大肠腺癌中存在差异，联合检测可以提高阳性率。CA125与CA199对左右半大肠腺癌神经侵犯具有指导意义，CA199对左右半大肠腺癌脉管侵犯具有指导意义。 　　[关键词] 大肠腺癌；血清肿瘤标志物；癌胚抗原；CA125；CA724；CA199 　　[中图分类号] R735 [文献标识码] A [文章编号] 1673-7210（2017）12（a）-0004-05 　　[Abstract] Objective To explore the value and significance of CEA， CA125， CA724 and CA199 in the diagnosis and judgment of left and right sided colorectal adenocarcinomas. Methods A total of 162 patients with colorectal adenocarcinomas were diagnosed by pathology from July 2015 to July 2016 in Renmin Hospital of Wuhan University were retrospectively analyzed， including 97 cases of left colorectal adenocarcinomas and 65 cases of right colorectal adenocarcinomas. The serum tumor markers and clinical and pathological parameters of the patients were collected and the differences between left and right colorectal adenocarcinomas were analyzed. Results The positive rate of CEA， CA125， CA724 and CA199 in the left colorectal cancer patients were 38.1%， 25.8%， 62.9% and 30.9%， and the positive rate of four serum markers was 59.8%. The positive rate of CEA， CA125， CA724 and CA199 in 53 patients with right colorectal cancer were 53.8%， 23.0%， 46.2% and 40.0%， respectively， and the positive rate of the combination of four markers was 64.6%. The positive rate of CA125 in the left half of the results of neural invasion of colorectal adenocarcinoma， CA199 in the right half of the results of neural colorectal adenocarcinoma， the difference was statistically significant， CA199 in the left and right semi-colorecta