脑膜瘤与AR以及MMP―2表达相关性研究.docVIP

脑膜瘤与AR以及MMP―2表达相关性研究 　　[摘要] 目的 研究脑膜瘤与雄激素受体（AR）及基质金属蛋白酶- 2（MMP- 2）表达的相关性。 方法 统计分析该院病理科2014年1月―2016年1月收集的50例脑膜瘤手术S mi psonⅠ～Ⅱ切除患者的石蜡标本的资料，对AR和MMP-2在良恶性脑膜瘤中的表达进行统计分析。结果 恶性、复发、未复发、良性患者的AR阳性率分别为80.0%、85.7%、27.3%、35.0%，MMP-2阳性率分别为80.0%、85.7%、24.2%、32.5%。恶性患者的AR阳性表达率和染色强度均明显比良性高（P0.05）；恶性和良性、良性复发的AR蛋白表达之间的差异有统计学意义（P0.05）；恶性患者的MMP-2阳性表达率和染色强度均明显比良性高（P0.05）；良性复发和良性未复发患者的MMP-2表达之间的差异有统计学意义（P0.05）。结论 AR和MMP-2表达与脑膜瘤有一定的相关性，可以作为对脑膜瘤良恶性进行鉴别的有效辅助诊断指标。 　　[关键词] 脑膜瘤；AR；MMP-2；相关性 　　[中图分类号] R651 [文献标识码] A [文章编号] 1674-0742（2016）10（a）-0021-03 　　Correlation Study of Meningioma with AR and MMP-2 Expression 　　ZHANG Gen-tang，LIU Wen-tao，LIU Jing-ping 　　Department of Neurosurgery，Qingdao Jiaozhou Central Hospital ，Qingdao，Shandong Province，266300 China 　　[Abstract] Objective To study the correlation of meningioma with Androgen receptor （AR） and matrix metalloproteinase - 2 （MMP-2） expression. Methods The data of 50 cases of meningioma surgery Smipson Ⅰ ～ Ⅱ patients with resected paraffin collected in our hospital from January 2014 to January 2016 were statistically analyzed， The AR and MMP 2 expressions in benign and malignant meningiomas were statistically analyzed. Results The positive rates of AR of malignant， relapse， without recurrence， benign were 80.0%， 85.7%， 27.3%， 35.0%， respectively， the positive rates of MMP-2 were 80.0%， 85.7%， 24.2%， 32.5%， respectively.The positive expression of AR and staining intensity of patients in malignant were significantly higher than in the benign （P 0.05）； malignant and benign， the difference between the AR protein expression in benign recurrent were significantly （P 0.05）； MMP-2 expression rate and staining intensity in patients with malignant were significantly higher than in the benign （P 0.05）； but the difference was benign and benign recurrent of patients without recurrence between MMP-2 expression was significantly （P 0.05）. Conclusion AR and MMP-2 expression have some relevance with meningioma， so can be regarded as effective diagnostic