脂联素基因T45G多态性和2型糖尿病相关性Meta分析.docVIP

脂联素基因T45G多态性和2型糖尿病相关性Meta分析 　　[摘要]目的 综合评价脂联素基因2号外显子第45位点基因与2型糖尿病（T2DM）的相关性。方法 电子检索2010～2015年中英文文献库关于脂联素基因T45G与T2DM的相关文献，以显性遗传模式、隐性遗传模式、加性遗传模式的三个指标进行综合汇总评价。结果 共计纳入6篇文献，中文2篇，英文4篇，其中观察组（T2DM）共计1119例，对照组（非T2DM）共计1043例。在显性遗传模式中，TT基因型与GG+TG基因型患T2DM危险系数等同[1.13（0.94，1.36）]，差异无统计学意义（P0.05）；在隐性遗传模式中，GG基因型明显高于TT+TG基因型患T2DM危险系数[0.67（0.45，0.98）]，差异有统计学意义（P0.05）；加性遗传模式中，GG基因型高于TT基因型患T2DM危险系数[0.18（0.12，0.25）]，差异有统计学意义（P0.05）。结论 脂联素基因2号外显子T45G多态性与T2DM具有一定的相关性，在隐性遗传模式和加性遗传模式中，G等位基因存在较高的致病风险。 　　[关键词]脂联素；2型糖尿病；基因；多态性；危险系数 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2016）06（c）-0008-04 　　[Abstract]Objective To evaluate the relationship of adiponectin gene exon 2 T45G polymorphism with type 2 diabetes mellitus （T2DM）.Methods Chinese-English document database was searched from 2010 to 2015，and the references of articles were also retrieved on adiponectin gene T45G associated with T2DM.The three indexes of dominant genetic model，recessive genetic model and additive genetic model were used for comprehensive evaluation summary.Results 6 Documents were included，Chinese 2 and English 4，wherein the observation group （T2DM） sumed to 1119 cases，in the control group （non-T2DM） sumed to 1043 cases.The dominant mode，the risk factor of T2DM between TT genotype and GG+TG genotype was equivalent [1.13 （0.94，1.36）]，with no statistical differenc （P0.05）.The recessive mode，the risk factor of T2DM in GG genotype was significantly higher than that of genotype TT+TG [0.67 （0.45，0.98）]，the difference was statistically significant （P0.05）；The additive genetic model，the risk factor of T2DM in GG genotype was significantly higher than that of TT genotype [0.18 （0.12，0.25）]，the difference was statistically significant （P0.05??.Conclusion Adiponectin gene exon 2 T45G polymorphism with T2DM has a certain relevance.In a recessive genetic mode and additive genetic model，G allele exists the higher risk. 　　[Key words]Adiponectin；Type 2 diabetes mellitus；Gene；Polymorphism；Risk factor 　　脂联素（adiponectin，APN）是一种可提升胰