补阳还五汤对急性脑梗死患者侧支循环影响.docVIP

补阳还五汤对急性脑梗死患者侧支循环影响 　　[摘要]目的 探讨补阳还五汤对急性脑梗死患者侧支循环的影响。方法 对2014年10月～2015年10月我院接收的40例急性脑梗死患者进行回顾性研究，将其分为研究组与对照组，两组均为20例，对照组采用调脂、活血化瘀、扩血管等西药进行治疗，研究组在对照组的基础上采用补阳还五汤治疗。通过酶联免疫吸附法（ELISA）检测血清中血管内皮生长因子（VEGF）及碱性纤维细胞生长因子（bFGF）水平，观察两组患者住院第1天及第7天神经功能缺失情况。结果 经治疗，两组患者的VEGF均明显升高，差异有统计学意义（P0.05）；治疗后，两组患者的神经功能缺损评分比较，差异有统计学意义（P0.01）；两组患者治疗后各神经功能缺损评分与治疗前比较，差异均有统计学意义（P0.01）。研究组与对照组的全血高切黏度、全血低切黏度、红细胞比例比较，差异均有统计学意义（P0.05）。结论 补阳还五汤能有效促进急性脑梗死患者血清中VEGF及bFGF功能的表达与供血状态，从而促进侧支循环的建立，很大程度上改善和保护脑组织的功能。 　　[关键词]补阳还五汤；急性脑梗死；侧支循环 　　[中图分类号]R743.33 [文献标识码]A [文章编号]1674-4721（2016）06（b）-0145-03 　　Effect of Buyanghuanwu Decoction on collateral circulation in patients with acute cerebral infarction 　　ZHENG Jin-song 　　Department of Cerebropathy，Quanzhou Traditional Chinese Medicine Hospital in Fujian Province，Quanzhou 362000，China 　　[Abstract]Objective To discuss the clinical effect of Buyanghuanwu Decoction on collateral circulation in patients with acute cerebral infarction （ACI）.Methods 40 ACI patients treated in our hospital from October 2014 to October 2015 were reviewed and randomly divided into study group and control group，each with 20 cases.Patients in the control group were given western drugs for lipid regulation，blood activation and stasis elimination，and vascular dilation，while patients in the study group were additionally given Buyanghuanwu Decoction.Levels of VEGF and bFGF were detected by ELISA and neurofunction deficits at day 1 and day 7 of hospitalization were observed.Results VEGF levels were enhanced in both groups after treatment.At day 7，the VEGF level was significantly higher in the study group than that in the control group （P0.05）；while after treatment，there was significant difference in neurofunction deficit between two groups （P 　　[Key words]Buyanghuanwu Decoction；Acute cerebral infarction；Collateral circulation 　　急性脑梗死的发病机制是高血压血管动脉硬化以及动脉粥样硬化而导致血管损伤，引发急性脑梗死。在日常生活中该病较为常见，其中动脉粥样硬化是导致其发病的主要病机[1]。有研究指出，脑血管存在侧支，急性脑梗死患者血流闭塞下侧支的血管形成能够对脑梗死面积的变化起到重要的调节作用。补阳还五汤具有活血、益气、通络、化瘀等作用，近年来在临床