规范治疗咳嗽变异性哮喘疗效及影响因素分析.docVIP

规范治疗咳嗽变异性哮喘疗效及影响因素分析 　　[摘要] 目的 探?规范治疗咳嗽变异性哮喘的疗效及影响因素。 方法 选取我院门诊2016年3月～2017年3月收治的86例咳嗽变异性哮喘患者作为研究对象，按治疗方式不同将患者分为观察组43例和对照组43例，对照组患者采用氨茶碱片常规治疗，观察组采用孟鲁司特钠规范治疗，记录两组治疗后临床疗效总有效率和治疗前后炎症因子[免疫球蛋白（IgE）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）]水平变化，分析影响其临床疗效的因素。 结果 观察组临床疗效总有效率83.72%显著高于对照组62.79%，差异有统计学意义（χ2=4.808，P=0.028）；治疗后观察组IgE、IL-8和TNF-α水平显著低于对照组，差异有统计学意义（P0.05）；总有效组患者咳嗽病程（11.11±5.14）显著短于无效组（15.88±5.11），差异有统计学意义（t=2.2485，P0.05）。 结论 规范治疗咳嗽变异性哮喘能有效减少炎症因子分泌和释放，改善患者临床症状，患者咳嗽病程越短，临床疗效越显著。 　　[关键词] 咳嗽变异性哮喘；孟鲁司特钠；疗效；因素 　　[中图分类号] R259 [文献标识码] A [文章编号] 2095-0616（2017）13-229-03 　　[Abstract] Objective To investigate the efficacy and influencing factors of standardized treatment for cough variant asthma （CVA）. Methods A total of 86 patients with CVA treated in our hospital from March 2016 to March 2017 were selected as the study subjects，and they were divided into the observation group （n=43） and the control group （n=43） according to the different treatment methods.And patients in control group were given aminophylline tablets routine therapy，and patients in observation group were treated with montelukast sodium.The total effective rate of the clinical efficacy after treatment，changes of inflammatory factors [immunoglobulin （IgE），interleukin-8 （IL-8） and tumor necrosis factor-α（TNF-α）] before and after treatment were recorded，and the influencing factors of clinical curative effect were analyzed. Results The total effective rate of the observation group was 83.72%，which was higher than that of the control group with 62.79%，therefore the difference was statistically significant （χ2=4.808，P=0.028）.The levels of IgE，IL-8 and TNF-α in the observation group were significantly lower than those in the control group （P0.05）.The cough duration in the total effective group was significantly shorter than that in the ineffective group [（11.11±5.14） vs （15.88±5.11）] （t=2.2485，P=0.0300）. Conclusion The standardized treatment of CVA can effectively reduce the secretion and release of inflammatory factors，