阿奇霉素序贯法联合炎琥宁治疗60例小儿支原体肺炎不良反应分析.docVIP

阿奇霉素序贯法联合炎琥宁治疗60例小儿支原体肺炎不良反应分析 　　摘 要 目的：探讨阿奇霉素序贯法联合炎琥宁治疗小儿支原体肺炎的不良反应。方法：选取小儿支原体肺炎120例，根据其治疗方法的不同可分为观察组和对照组各60例，对照组给予阿奇霉素序贯法治疗，观察组在此基础上给予炎琥宁，比较两组临床疗效，分别检测两组肠道菌群失调程度，观察不良反应。结果：观察组的治疗有效率明显高于对照组治疗（96.67% vs 76.67%，P0.05），停药后症状缓解。结论：阿奇霉素序贯法联合炎琥宁治疗小儿支原体肺炎较单纯给予阿奇霉素治疗效果更显著，临床上应注意合理用药，减少不良反应发生。 　　关键词 阿奇霉素 序贯法 炎琥宁 不良反应 　　中图分类号：R725.1 文献标识码：C 文章编号：1006-1533（2017）03-0041-03 　　Analysis of adverse reactions of azithromycin sequential therapy combined with yanhuning in the treatment of 60 cases of children with mycoplasma pneumonia* 　　LU Fengling** 　　（Department of Pharmacy， Children’s Hospital of Yuexiu District， Guangzhou City， Guangzhou 510115， China） 　　ABSTRACT Objective： To analyze the adverse reactions of azithromycin combined with Yanhuning in the treatment of children with mycoplasma pneumonia. Methods： One hundred and twenty cases of children with mycoplasma pneumonia were divided into an observation group and a control group with 60 cases each based on different treatment methods. The control group was given azithromycin sequential therapy while the observation group was additionally given Yanhuning. The clinical efficacy was compared. The intestinal flora imbalance in the two groups was detected and the adverse reactions were observed. Results： The effective rate was significantly higher in the observation group than in the control group （96.67% vs 76.67%， P0.05）. Conclusion： Azithromycin sequential therapy combined with Yanhuning for the treatment of children with mycoplasma pneumonia can improve the therapeutic effect. Great attention should be paid to rational use of drugs so as to reduce the incidence of adverse reactions. 　　KEy WORDS azithromycin； sequential method； Yanhuning ； adverse reactions 　　支原体肺炎是由肺炎支原体感染而导致的肺炎，伴急性呼吸道感染，严重者会引起呼吸衰竭甚至死亡，婴幼儿支原体肺炎发病年龄提前且呈逐年升高的趋势[1]。近几年来，阿奇霉素联合炎琥宁治疗小儿支原体肺炎已成为研究的热点，但对阿奇霉素贯法联合炎琥宁治疗小儿支原体肺炎的不良反应分析的报道较少，本研究探讨阿奇霉素序贯法联合炎琥宁治疗小儿支原体肺炎的不良反应分析，现报道如下。 　　1 资料与方法 　　1.1 临床资料 　　选取我院2013年12月至2016年5月小儿支原体肺炎120例，根??其治疗方法的不同可分为观察组和对照组各60