长期吸入小剂量布地奈德对哮喘患儿骨密度影响.docVIP

长期吸入小剂量布地奈德对哮喘患儿骨密度影响 　　【摘要】 目的 研究分析长期吸入小剂量布地奈德对哮喘患儿骨密度的影响。方法 80例哮喘患儿作为观察组， 随机分为A、B两组， 各40例， 所有患儿均给予长期吸入布地奈德治疗， 剂量分别为100 μg、150 μg， 持续时间为9～12个月， 再选取40例正常体检儿童作为对照组。对比分析观察组A、B两组患儿临床治疗效果。结果 所有患儿临床治疗总有效率均为100.0%；治疗后骨密度指标与治疗开始时及正常儿童相比， 差异无统计学意义（P0.05）。结论 长期吸入小剂量布地奈德对于哮喘患儿具有较高临床应用价值， 疗效确切， 不影响哮喘患儿骨密度， 值得临床大力推广。 　　【关键词】 小剂量布地奈德；哮喘；骨密度 　　DOI：10.14163/j.cnki.11-5547/r.2015.11.006 　　Influence of long-term inhalation of small dose of budesonide on bone mineral density in asthma children CHENG Ru-wan， HE Bing. Guangdong Yangjiang City Hospital of traditional Chinese Medicine， Yangjiang 529500， China 　　【Abstract】 Objective To research the influence of long-term inhalation of small dose of budesonide on bone mineral density in asthma children. Methods A total of 80 asthma children were taken as the observation group， and they were randomly divided into group A and group B， with 40 cases in each group. All children received treatment by long-term inhalation of small dose of budesonide， their treatment doses were respectively 100 μg and 150 μg for 9～12 months. Another 40 healthy children were selected as controal group. Curative effects of group A and group B were compared and analyzed. Results The clinically total effective rate of all the children was 100%， and the difference of bone mineral density before and after treatment had no statistical significance， compared with healthy children （P0.05）. Conclusion Long-term inhalation of small dose of budesonide provides highly clinical application value with precise effect in treating asthma children. This method has no influence on bone mineral density， and is worth widely clinical promotion. 　　【Key words】 Small dose of budesonide； Asthma； Bone mineral density 　　哮喘是一种会反复影响和危害患儿健康的慢性呼吸道变应性炎症疾病[1]。由于其发病原因多种多样， 发病机理相对复杂， 尤其是患儿的自身状况具有特殊性和差异性， 极大程度的增加了治疗难度[2]。本次研究选取本院收治的80例哮喘患儿给予长期吸入小剂量布地奈德进行治疗， 取得令人满意的效果。现将治疗对患儿骨密度的影响报告如下。 　　1 资料与方法 　　1. 1 一般资料 选取2012年10月～2013年10月在本院确诊收治的80例哮喘患儿作为观察组， 将观察组患儿随机分为A、B两组， 各40例， A组患儿男22例， 女18例；年龄3～8