阿德福韦酯与干扰素联合治疗慢性乙型肝炎临床观察.docVIP

阿德福韦酯与干扰素联合治疗慢性乙型肝炎临床观察 　　[摘要] 目的 观察阿德福韦酯与干扰素联合治疗慢性乙型肝炎的临床疗效。 方法 选取2013年1月～2015年1月我院收治的慢性乙型肝炎患者100例作为临床研究对象，随机分为观察组与对照组，每组各50例，两组患者均根据病情予保肝、营养支持等常规治疗。对照组予干扰素治疗，每次5 MU，每周3次，肌肉注射；观察组同时加用阿德福韦酯胶囊10 mg，1次/d，口服，疗程12个月。比较两组治疗后的完全应答率、HBV-DNA转阴率。 结果 观察组治疗3、6、12个月后HBV-DNA转阴率分别为32.00%、40.00%、52.00%，分别高于对照组，差异具有统计学意义（P0.05）。观察组治疗12个月后，2例无应答，观察组的完全应答率达60.0%显著高于对照组的30.0%，差异具有统计学意义（P0.05）。 结论 阿德福韦酯与干扰素联合治疗慢性乙型肝炎完全应答率高，可有效抑制病毒复制，值得推广和应用。 　　[关键词] 慢性乙型肝炎；阿德福韦酯；干扰素；慢性乙型肝炎 　　[中图分类号] R512.62 [文献标识码] B [文章编号] 1673-9701（2015）34-0086-03 　　Clinical observation of adefovir dipivoxil combined with interferon for treating chronic hepatitis B 　　ZHUANG Jintian 　　Department of Infectious Diseases，the People`s Hospital of Lanling County in Shandong Province， Lanling 277799， China 　　[Abstract] Objective To observe the clinical efficacy of adefovir dipivoxil combined with interferon for treating chronic hepatitis B. Methods From January 2013 to January 2015， 100 patients with chronic hepatitis B patients were randomly divided into observation group and control group， 50 cases in each group， two groups of patients were treated by 5 MU， times per week， 3 times per week. Observation group with Adefovir Dipivoxil Capsules 10 mg， 1 time/d， oral， treatment for 12 months. The complete response rate of the two groups and the negative rate of HBV-DNA were compared after treatment. Results The observation group of 3， 6 and 12 months after treatment HBV-DNA negative rate was 32.00% and 40.00%， 52.00%， respectively， higher than the control group， with significant difference（P0.05）. After 12 months of observation group， 2 patients had no response， the complete response rate was 60.0% in the observation group， and the complete response rate was 30.0% in the control group（P0.05）. Conclusion Combined treatment of adefovir Dipivoxil and interferon in chronic hepatitis B complete response rate is high， can effectively inhibit viral replication， it is worth popularization and application. 　　[Key words] Adefov