阻塞性睡眠呼吸暂停低通气综合征合并稳定型冠心病患者采用持续正压通气治疗时心功能变化研究.docVIP

阻塞性睡眠呼吸暂停低通气综合征合并稳定型冠心病患者采用持续正压通气治疗时心功能变化研究 　　[摘要] 目的 研究阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并稳定型冠心病患者采用持续正压通气治疗时的心功能变化。 方法 OSAHS合并稳定型冠心病患者56例，健康人46例及稳定型冠心病患者51例均进行多导睡眠呼吸监测及动态心电图监测，并对OSAHS合并稳定型冠心病患者进行持续正压通气治疗。 结果 OSAHS患者AHI、SDNN、SDANN、RMSSD及PNN50指标均显著好于其他研究对象，且重度OSAHS患者这五项指标显著性高于其他患者（P0.05）。治疗后OSAHS患者这五项指标显著性低于治疗前（P0.05）。 结论 OSAHS合并冠心病患者心率失常发生率高于冠心病患者，但这些患者采用持续正压通气治疗后心功能明显改善，心率失常发生率显著降低。 　　[关键词] 冠心病；OSAHS；心率异常；正压通气；疗效 　　[中图分类号] R56；R541.4 [文献标识码] B [文章编号] 1673-9701（2014）32-0013-03 　　Heart function change study of patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） and coronary heart disease （CHD） in the treatment of continuous positive airway pressure 　　JI Yuehua1 LU Huadong2 　　1.Electrocardiographic Room， the Central Hospital of Huzhou City in Zhejiang Province， Huzhou 313000，China；2. Department of Respiration Medicine， the Central Hospital of Huzhou City in Zhejiang Province， Huzhou 313000，China 　　[Abstract] Objective To study the heart function change of patients with OSAHS and CHD in the treatment of continuous positive airway pressure. Methods A total of 56 patients with OSAHS and CHD， 46 healthy people and 51 patients with CHD in our hospital were received polysomnography and dynamic electrocardiogram. And the patients with OSAHS and CHD were also received the treatment of continuous positive airway pressure. Results The levels of AHI， SDNN， SDANN， RMSSD and PNN50 of patients with OSAHS and CHD were significantly higher than these of others（P0.05）. And the levels of AHI， SDNN， SDANN， RMSSD and PNN50 of patients with severe OSAHS group were significantly higher than those of other patients（P0.05）. The levels of AHI， SDNN， SDANN， RMSSD and PNN50 of patients with OSAHS and CHD after treatment were significantly lower（P0.05）. Conclusion Arrhythmia incidence rate of patients with OSAHS and CHD is higher than patients with CHD. And the arrhythmia incidence rate of patients with OSAHS and CHD after cintinuous positive airway pressure is declined. 　　[Key words]