阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素和CRP水平变化及相关性研究.docVIP

阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素和CRP水平变化及相关性研究 　　[摘要] 目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清中瘦素、C反应蛋白水平（CRP）变化与OSAHS病情严重程度的关系，以及两因子在疾病中的相关性。方法：采用酶联免疫吸附法（ELISA）测定30例男性OSAHS患者[根据呼吸暂停低通气指数（AHI）将患者分为轻、中、重度三组]和20例健康者（对照组）血清瘦素、CRP水平，利用统计学方法，比较各组间的差异并分析瘦素与CRP的相关性。结果：①OSAHS组血清瘦素和CRP水平均较对照组有增高。②OSAHS组：自轻、中至重度组，瘦素水平逐渐增高，组间两两比较差异均有统计学意义。而CRP水平重度组较轻中度组有明显增高，轻中度之间差异无统计学意义。③相关分析表明：瘦素与AHI、CRP呈正相关。结论：OSAHS患者血清瘦素、CRP水平均较健康人明显增高，且与其严重程度相关。同时瘦素与CRP呈正相关，表明两者可能在OSAHS的发展过程中有协同作用。 　　[关键词] 阻塞性睡眠呼吸暂停低通气综合征；瘦素；C反应蛋白；酶联免疫吸附法 　　[中图分类号] R441.8；R563.8 [文献标识码]A[文章编号]1674-4721（2011）08（b）-０16－０2 　　 　　The changes of serum leptin and CRP levels in patients with obstructive sleep apnea-hypopnea syndrome and the correlation 　　QIN Ruijun1,WANG Ping2*, WANG Hong2, QIAO Kehong2, MA Yanbing2, SHANG Xiaofeng2, ZHENG Shuguang2, GUO Changcheng2, YIN Huiting2, LI Hong2 　　Department of Respiratory Diseases, Central Hospital in Taiyuan City, Shanxi Province, Taiyuan, 030009, China 　　[Abstract] Objective: To investigate the relationship between the changes of serum leptin and C-reactive protein (CRP) levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and the severity of OSAHS, and to study two factors′correlation. Methods: Using enzyme-linked immunosorbent assay (ELISA) measured serum leptin and C-reactive protein (CRP) between 30 male patients with OSAHS [on the apnea-hypopnea index (AHI), the case group was divided into mild, moderate and severe] and 20 healthy persons (control group). And the differences between groups were compared and the correlation between leptin and CRP were analyzed by statistical methods. Results: ①Serum levels of leptin and CRP in OSAHS group were significantly higher than those in the control group. ②OSAHS groups: From mild to severe group, leptin levels gradually increased and the difference between two groups were statistically significant. The CRP level of severe group was significantly higher than moderate group, and there was no statistically significant difference