预注右美托咪定镇静效应及其对全麻患者气管插管反应影响分析.docVIP

预注右美托咪定镇静效应及其对全麻患者气管插管反应影响分析 　　[摘要] 目的 对预注右美托咪定的镇静效应及其对全麻患者气管插管反应的影响进行分析。 方法 选取2013年3～9月于全麻下进行甲状腺次全切除术患者100例，随机分为两组。对照组患者予麻醉诱导前静脉泵注生理盐水，而观察组患者泵注等量右美托咪定，后进行气管插管，对两组患者不同时间镇静情况、意识消失时间及相关不良反应分析比较。 结果 观察组中患者意识消失时间、BIS下降至45的时间短于对照组（P0.05）；观察组麻醉诱导期出现不良反应发生率明显低于对照组（P0.05）。结论 预注右美托咪定的镇静效果较好，且对于全麻患者气管插管不良反应较小。 　　[关键词] 右美托咪定；镇静效应；全麻；气管插管 　　[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701（2014）23-0062-03 　　[Abstract] Objective To analyze the sedative effect of dexmedetomidine pre-injection and its effect on intratracheal intubation response for patients under general anesthesia. Methods One hundred patients who received subtotal thyroidectomy under general anesthesia from March 2013 to September 2013 were selected and randomly assigned to two groups. The control group was intravenously injected with normal saline before an anesthesia induction，and the observation group was intravenously injected with an equal amount of dexmedetomidine before the intratracheal intubation. Sedation at different points of time，time needed for loss of consciousness，and incidence of adverse events in the two groups were analyzed and compared. Results The time needed for loss of consciousness and the time for BIS value decreasing to 45 in the observation group were shorter than those in the control group（P0.05）； The incidence of adverse events in the observation group during anesthesia induction was significantly lower than that in the control group（P0.05）. Conclusion The pre-injection of dexmedetomidine has a better sedative effect，and has minor adverse events for patients receiving intratracheal intubation under general anesthesia. 　　[Key words] Dexmedetomidine； Sedative effect； General anesthesia； Intratracheal intubation 　　临床上采取预注右美托咪定能有效改善患者临床镇静效果，且对于全麻气管插管患者的不良反应较小[1]。本文通过比较于麻醉诱导前静脉泵注生理盐水和右美托咪定的镇静效果、意识消失时间及临床不良反应等，从而对预注右美托咪定的镇静效应及其对全麻患者气管插管反应的影响进行研究，现报道如下。 　　1 资料与方法 　　1.1一般资料 　　选取鹤壁市中医院手术室2013年3～9月间于全凭静脉麻醉下进行甲状腺次全切除术患者100例，所选患者未出现甲状腺功能亢进、严重心肺疾病、困难插管、甲状腺高功能腺瘤、肌酐或尿素氮水平值异常、肝功能严重障碍等，且患者于疾病治疗近期未服用阿