E―cadherin和肿瘤侵袭转移相关性研究进展.docVIP

E―cadherin和肿瘤侵袭转移相关性研究进展 　　摘 要：恶性肿瘤的侵袭、转移特性使其成为癌症患者死亡的首要原因，不仅给治疗带来了一定的难度，更让患者承受了身体及心理的巨大痛苦。探究恶性肿瘤侵袭、转移的机制，并针对其相关分子标志物寻找抑制靶点，是临床医务工作者及基础医学研究者面临的巨大挑战。恶性肿瘤的侵袭、转移机制是一个多方面因素相互作用的复杂过程，包括了肿瘤细胞自身生物学行为、肿瘤细胞生存的微环境、及各种细胞因子、信号通路等因素。上皮-间质转化是近年来肿瘤侵袭、转移领域的研究热点，而上皮型钙黏蛋白是上皮-间质转化过程中一种主要的蛋白标志物，更好的理解上皮型钙黏蛋白与上皮-间质转化的关系及它们在癌症进展中所涉及的机制，能够为晚期转移性肿瘤治疗及预防的相关研究提供理论及实验依据。因此本文就上皮-间质转化与肿瘤侵袭、转移的研究作一综述。 　　关键词：E-cadherin；上皮-间质转化；肿瘤；侵袭；转移 　　中图分类号：R73-37 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.002 　　文章编号：1006-1959（2018）03-0003-03 　　Abstract：The invasion and metastasis of malignant tumor make it the leading cause of death in cancer patients.It not only brings some difficulties to the treatment，but also endures great physical and psychological suffering.To explore the mechanism of invasion and metastasis of malignant tumor and find the target of inhibition against its related molecular markers is a great challenge for clinical medical workers and basic medical researchers.Malignant tumor invasion and metastasis mechanism is a complex process of interaction of many factors，including the biological behavior of tumor cells themselves，the microenvironment of tumor cells survival， and various cytokines，signaling pathways and other factors.Epithelial-mesenchymal transition（EMT）is a hotspot in the field of tumor invasion and metastasis in recent years.E-cadherin is a major protein marker in EMT，and better Understanding the relationship between E-cadherin and EMT and their mechanisms involved in cancer progression can provide theoretical and experimental evidence for the research on the treatment and prevention of advanced metastatic tumors.Therefore，this article reviews E-cadherin and tumor invasion and metastasis. 　　Key words：E-cadherin；Epithelial-mesenchymaltransition；Tumor；Invasion；Metastasis 　　侵袭、转移是恶性肿瘤致患者死亡的首要原因。上皮-间质转化（epithelial-mesenchymaltransition，EMT）是肿瘤侵袭、转移的一重要过程，其意义是肿瘤细胞在发生侵袭、转移时从上皮表型转变为间质表型，从原发灶脱落进入转移途径，这一过程伴随着各种蛋白标志物的改变与相关信号通路的激活或抑制。上皮型钙黏蛋白（E-cadherin）是这一过程中最为主要的蛋白标志物，其所介导的上皮细胞间的粘