青中年脑梗死和颈动脉不稳定斑块D―二聚体Hcy相关因素分析.docVIP

青中年脑梗死和颈动脉不稳定斑块D―二聚体Hcy相关因素分析 　　【摘要】 目的：分析脑梗死患者与颈动脉不稳定斑块、D-二聚体、同型半胱氨酸（homocysteine，Hcy）的相互关系。方法：选取2012年2月-2014年2月在本院住院的60例青中年脑梗死患者作为试验组，同时在同时期住院的高血压患者中选取无脑梗死症状的60例作为对照组。两组患者分别检测颈动脉彩超，查血清D-二聚体及Hcy水平，并对此进行比较。结果：试验组的颈动脉IMT严重程度、斑块硬化程度及颈动脉狭窄程度均明显大于对照组，差异均有统计学意义（P0.05）。试验组患者的血清D-二聚体、Hcy水平均明显高于对照组，差异均有统计学意义（P0.05）。结论：颈动脉不稳定斑块、D-二聚体、Hcy是急性脑梗死发生的重要危险因素，颈动脉不稳定斑块、D-二聚体、Hcy联合检测有助于预测脑梗死的发生。 　　【关键词】 脑梗死； 颈动脉不稳定斑块； D-二聚体； 同型半胱氨酸 　　【Abstract】 Objective：To analyze the relationship of cerebral infarction patients with carotid unstable plaque，serum D-dimer and Hcy levels.Method：60 young and middle-aged patients with cerebral infraction admitted to our hospital from February 2012 to February 2014 were selected as the experimental group，60 patients without symptoms of cerebral infarction who selected from patients with hypertension in the same period were regarded as the control group.They were detected by carotid artery color Doppler ultrasound，the serum levels of D-dimer and Hcy were tested，and compared all indexes.Result：The carotid IMT severity，pplaque hardening degree and carotid stenosis degree of the experimental group were significantly larger than those of the control group，the differences were statistically significant（P0.05）.The serum D-dimer and Hcy levels of the experimental group were statistically higher than those of the control group，the differences were statistically significant（P0.05）.Conclusion：The carotid unstable plaque，serum D-dimer and Hcy are the important risk factors of acute cerebral infarction，carotid unstable plaque with the serum level of D-dimer and Hcy are helpful for the early prediction of occurrence of cerebral infraction. 　　【Key words】 Cerebral infraction； Carotid unstable plaque； D-dimer； Hcy 　　First-author’s address：The Fifth People’s Hospital of Jiaozuo City，Jiaozuo 454002，China 　　doi：10.3969/j.issn.1674-4985.2015.35.020 　　在临床工作中，急性脑梗死占整个脑血管病患者的80%以上，病残率较高，近些年来发现青中年人的发病率逐渐增加，脑梗死会对本人、单位及社会带来危害及不利影响，其有效的治疗及预防显得尤为重要[1]。颈动脉不稳定斑块、D-二聚体、同型半胱氨酸是脑