血清铁蛋白水平和老年2型糖尿病肾病相关性研究.docVIP

血清铁蛋白水平和老年2型糖尿病肾病相关性研究 　　[摘要] 目的 探讨老年2型糖尿病肾病与血清铁蛋白水平的相关性，为临床早期防治2型糖尿病肾病提供帮助。方法 选取我院2014年6月～2015年12月300例住院治疗的老年2型糖尿病患者，根据尿微量白蛋白水平分为正常尿微量白蛋白组、微量尿白蛋白组、大量尿白蛋白组，并选我院同期健康体检的正常人100例为正常对照组，分别测量血清铁蛋白、尿微量白蛋白、尿β2-微球蛋白（β2-MG）、肾功能、胰岛素等项目。 结果 老年2型糖尿病尿微量白蛋白组，血清铁蛋白水平高于正常对照组和正常尿微量白蛋白组，差异有统计学意义（P0.05）；相关分析提示血清铁蛋白水平与尿微量白蛋白排泄成正相关，差异有统计学意义（P0.05）。 结论 血清铁蛋白增高的发生率随糖尿病肾功能受损程度增加而增高。 　　[关键词] 血清铁蛋白；老年2型糖尿病；糖尿病肾病；尿微量白蛋白 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1673-9701（2016）13-0024-03 　　Correlation research between serum ferritin level and senile type 2 diabetic nephropathy 　　WU Shaoyang YANG Xinming 　　Department of Nuclear Medicine， the Third Hospital of Nanchang City， Nanchang 330009， China 　　[Abstract] Objective To investigate the relationship between serum ferritin and diabetic in elderly patients（age60 years） with type 2 diabetic to provide a method in treatment and prognosis on type 2 diabetes patients. Methods 300 hospitalized patients with type 2 diabetic from June 2014 to December 2015 were divided into three groups， according to the results of proteinuria quantitation，including normal albuminuria group， microalbuminuria group and mass albuminuria group. 100 health examinations for the same period as the control group. All of the groups had the derection of serum ferritin， micoralbuminuria， urinary β2-albumin，renal function，insulin. Results As to the albuminuria group， serum ferritin was higher than that the control group and the normal urine group， there was significantly difference（P0.05）. Correlation analysis showed that serum ferritin and urinary micoralbuminuria excretion were proportional relationship， there was significantly difference（P0.05）. Conclusion The incidence of serum ferritin increased with the increase of the degree of diabetic nephropathy function damaged in elderly patients of type 2. 　　[Key words] Serum ferritin； Type 2 diabetic mellitus； Diabetic nephropathy； Micoralbuminuria 　　近年来国内外一些研究提示铁在2型糖尿病肾病发病中起着重要作用，两者之间有着重要的相关性和可逆性。机体铁储量越多，发生2型糖尿病、糖尿病肾病的机率越大[1]。血清铁蛋