聚蛋白多糖酶和膝骨关节炎相关性研究.docVIP

聚蛋白多糖酶和膝骨关节炎相关性研究 　　【摘要】 目的 观测并探讨膝骨关节炎关节液及血清中聚蛋白多糖酶（ADAMTSs）水平与病变程度的关系。方法 单侧膝骨关节炎87例中,早期为45例，中晚期为42例。检测其患侧膝关节液和血清中ADAMTSs水平。以健康志愿者30例为正常对照组。结果 膝骨关节炎患者关节液及血清中ADAMTSs水平均高于正常对照组,随着病变程度加重,膝关节液及血清中ADAMTSs水平显著增加,关节液与血清中ADAMTSs水平存在线性相关关系。结论 ADAMTSs水平在骨关节炎患者膝关节液和血清中均升高,与病变程度密切相关,检测关节液及血液该种指标有助于病情早期诊断。 　　【关键词】 骨关节炎;膝关节;聚蛋白多糖酶 　　The relationship between ADAMTSs and knee osteoarthritis DEN Zi-yu, SUN Yi, LIN Jun, WAN Yin, et al.Departmet of Geriatric;Departmet of Laboratory; Departmet of Rheumatology and Immunology, The First Hospital of Yunnan Province, Kunming 650032, China 　　【Abstract】 Objective To observe and discuss the relationship between levels of ADAMTSs in synovial fluid and knee osteoarthritis in serum and the degree of pathological change. Methods Among 87 patients with single-side knee osteoarthritis, 45 of them suffered from early-stage knee osteoarthritis, and 42 of them from medium-later-stage knee osteoarthritis. Examined levels of ADAMTSs in synovial fluid and serum. The control group was 30 healthy volunteers.Results Levels of ADAMTSs in synovial fluid and serum in these patients bodies were higher than those of the control group. As the degree of pathological change becomes increasingly serious, such levels were increased significantly, and there was linear relationship between levels of ADAMTSs in synovial fluid and those in serum. Conclusion Levels of ADAMTSs in synovial fluid and serum in bodies of persons suffering from knee osteoarthritis are increased, and there is close relationship between the degrees of pathological change. Examination of levels of ADAMTSs in synovial fluid and serum facilitates diagnosis at early stage. 　　【Key words】 Osteoarthritis; Knee;ADAMTSs 　　骨关节炎（osteoarthritis,OA）是中老年人最常见的骨关节疾病，其最早出现的改变是关节软骨的损伤。软骨破坏的病理表现是软骨外基质（extracellular matrix,ECM）的降解，而聚蛋白多糖的丢失是这一过程的主要病理表现之一［1］。正常、退行性变的关节软骨在代谢转化过程中释放的代谢产物进入血液和关节液中，聚蛋白多糖酶（ADAMTSs）就是这样一种相对特异的软骨代谢标志物。本研究通过检测血液和关节液中的ADAMTSs，以探讨其与OA的相关关系及在OA早期诊断中的意义。 　　1 资料与方法 　　1.1 一般资料 为2008年11月至2