视黄醇结合蛋白4 超敏C反应蛋白和代谢综合征痰瘀辨证关系研究.docVIP

视黄醇结合蛋白4 超敏C反应蛋白和代谢综合征痰瘀辨证关系研究 　　（海宁市人民医院，浙江 海宁 314400） 　　摘 要：目的：探讨视黄醇结合蛋白4（RBP4）、超敏C反应蛋白（hs-CRP）与代谢综合征（MS）痰瘀辨证之间的关系。方法：将60例MS患者中医辨证分为痰浊瘀阻型与非痰浊瘀阻型两组，另设正常对照组30例。测定3组患者的血清RBP4、血清hs-CRP、空腹血糖（FPG）、空腹胰岛素（FINS），胰岛素抵抗指数（HOMA-IR），并测定身高、体重、腰围（WC）、血压，计算体重指数（BMI）。结果：痰浊瘀阻组BMI、WC、RBP4、hs-CRP、HOMA-IR各值均高于非痰浊瘀阻组（P0.05），显著高于正常组（P0.01）。非痰浊瘀阻组hs-CRP 高于正常组（P0.05），BMI、WC、RBP4、HOMA-IR显著高于正常组（P0.01）。RBP4与WC呈正相关（r0.014），与BMI、hs-CRP、HOMA-IR密切关系（r值分别为0.001、0.006、0.001）。hs-CRP与BMI 、HOMA-IR呈正相关（r值分别为0.023、0.038）。结论：RBP4、hs-CRP与痰瘀关系密切。明确了痰瘀在MS中重要性。RBP4、hs-CRP可作为中医辨证诊治代谢综合征的客观指标。 　　关键词：视黄醇结合蛋白4；超敏C反应蛋白；代谢综合征；痰瘀 　　中图分类号：R285.6文献标识码：A文章编号：1673-7717（2011）03-0557-03 　　Study on Relationship Between Retinol Binding Protein 4 and High-sensitive C-reactive 　　Protein and Symptoms and Signs of Phlegm-blood Stasis of metabolic syndrome 　　ZHU Ya-qin,ZHANG Wei-cheng,YU Zi-xiang ,TANG Liang-chun 　　（The People’s Hospital of Haining, Haining 314400,Zhejiang,China） 　　Abstract:Objective：To investigate the relationship between retinol binding protein 4（RBP4），high-sensitive c-reactive protein（hs-CRP） and symptoms and signs of phlegm-blood stasis of metabolic syndrome （MS）.Methods：sixty cases of MS were divided into groups of coagulation of phlegm-blood stasis type and non- coagulation of phlegm-blood stasis type. Thirty healthy people were taken as normal control group. RBP4，hs-CRP，fasting plasma glucose （FPG），fasting insulin（FINS） were detected and Homeostasismodel assessment of insulin resistance（HOMA-IR）was calculated. Height, weight, waist circumference（WC）, blood pressure and BMI were measured. Result：BMI，WC，RBP4，hs-CRP，HOMA-IR in coagulation of phlegm-blood stasis group higher than those of the non- coagulation of phlegm-blood stasis group（P0.05）and were significantly higher than those of the healthy persons（P0.01）. Hs-CRP in non- coagulation of phlegm-blood stasis group higher than those of the healthy persons（P0.05）. BMI、WC、RBP4、HOMA-IR in non- coagulation of phlegm-blood stasis group are signifi