复方龙星片联合西医常规治疗慢性阻塞性肺疾病稳定期痰热蕴肺证临床的研究.docVIP

复方龙星片联合西医常规治疗慢性阻塞性肺疾病稳定期痰热蕴肺证临床的研究 　　摘要：目的 ?^察复方龙星片联合西医常规治疗慢性阻塞性肺疾病（COPD）稳定期痰热蕴肺证的临床疗效。方法 采用随机数字表法将120例中重度COPD稳定期患者随机分为治疗组和对照组各60例。对照组予西医常规治疗；治疗组在对照组基础上予复方龙星片，每次5粒，每日3次，口服。均4周为1个疗程，连续治疗2个疗程，随访8周。观察治疗前后及随访时中医症状积分、肺功能、6 min步行距离（6MWD）和COPD评估测试（CAT）评分。监测不良反应及安全性。结果 治疗组总有效率为88.33%（53/60），对照组为73.33%（44/60），治疗组明显优于对照组（P0.05）。与本组治疗前比较，2组治疗后、随访时中医症状积分及CAT评分明显降低，差异有统计学意义（P0.05）；治疗组治疗后、随访时中医症状积分、CAT评分低于对照组，差异有统计学意义（P0.05）。与本组治疗前比较，治疗组随访时FEV1%、FEV1/FVC、6MWD明显改善（P0.05），对照组6MWD明显改善（P0.05）；治疗组治疗后、随访时同一时点肺功能和6MWD改善情况优于对照组（P0.05）。2组均未见肝肾功能、血尿常规、心电图异常，2组不良反应各1例。结论 复方龙星片联合西医常规治疗COPD稳定期痰热蕴肺证可有效改善患者持续呼吸道症状、肺功能及CAT评分。 　　关键词：慢性阻塞性肺疾病；痰热蕴肺证；复方龙星片；肺功能 　　DOI：10.3969/j.issn.1005-5304.2018.05.006 　　中图分类号：R259.63 文献标识码：A 文章编号：1005-5304（2018）05-0023-04 　　Clinical Study on Compound Longxing Tablets in Treatment of Chronic Obstructive Pulmonary Disease with Syndrome of Phlegm-heat Obstructing Lung 　　XU Gui-hua， SHI Miao-yan， ZHANG Wei， SONG Xiu-ming， ZHANG Yi-bao 　　Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China 　　Abstract： Objective To observe the clinical efficacy of Longxing Tablets in treating chronic obstructive pulmonary disease （COPD） with syndrome of phlegm-heat obstructing lung. Methods Totally 120 patients with COPD were randomly divided into the treatment group and the control group， with 60 cases in each group. The control group was treated with the conventional Western medicine， while the treatment group was additionally treated with compound Longxing Tablets based on routine therapy with Western medicine， five tablets per day， three times a day， orally. Four weeks was one treatment course， for two courses， with follow-up for eight weeks. The scores of TCM syndrome， pulmonary function， 6MWD and CAT questionnaire were observed before and after treatment. Adverse reactions and safety were observed. Results The clinical total effective rate were 88.33% （53/60） in the treatment group and 73.33% （44/60） in the control gro