新余市渝水区154例帕金森病危险因素调查的研究.docVIP

新余市渝水区154例帕金森病危险因素调查的研究 　　【摘要】 目的：研究新余市渝水区门诊帕金森病相关危险因素。方法：病例组为2013年1月-2014年12月新余市渝水区来本院帕金森病专病门诊就诊的154例PD患者。对照组为同期新余市渝水区来本院神经内科就诊的154例其他患者。按照1∶1进行统计研究。结果：大专以上教育程度与PD的发生有显著性的联系（OR=0.23，95% CI=0.11-0.60），受教育程度越高是PD的危险因素。研究结果表明有家族史是PD的危险因素（OR=0.31，95% CI=0.15-0.68）。研究结果未发现与PD的发生有关，病例组和对照组之间的分布无显著性差别。结论：本文研究虽然排除了吸烟和饮酒对帕金森的影响，但不排除吸烟和饮酒对心脑血管疾病和神经系统疾病的危险因素影响。 　　【关键词】 新余市； 帕金森病； 相关危险因素 　　【Abstract】 Objective：To research the related risk factors of Parkinson’s disease in clinic Yushui District of Xinyu city.Method：154 PD patients from Xinyu Yushui district admitted to Parkinson’s disease special clinic of our hospital from January 2013 to December 2014 were selected as the case group.The 154 other patients for the same period in Xinyu City Yushui district to visit our hospital department of internal medicine were selected as the control group.The two groups were researched statistically according to 1∶1.Result：College degree or above education level had significant relationship with the incidence of PD（OR=0.23，95% CI=0.11-0.60），the higher education level was the risk factor of PD.The results showed that the family history was a risk factor for PD（OR=0.31，95% CI=0.15-0.68）.There was no significant difference in the distribution between the case group and the control group.The results were not found to have a significant difference between the patients and the control group.Conclusion：This study excludes the effect of smoking and alcohol drinking on Parkinson，but don’t rule out the risk factors of smoking and alcohol drinking on cardiovascular and cerebrovascular diseases and neurological diseases. 　　【Key words】 Xinyu city； Parkinson’s disease； Related risk factors 　　帕金森（Parkinson’s disease，PD）一般认为是中老年患者神经系统功能退化导致的进行性疾病。发病年龄较大，一般大于40岁，40岁以下患者较为罕见。帕金森患者部分合并多脏器退化等其他合并症[1-3]。因为帕金森病例多为单发病理，遗传因素对帕金森的发病率几乎无影响，所以，本文通过研究对环境因素和生活习惯因素进行拟合研究和回归研究。 　　1 资料与方法 　　1.1 一般资料 选取2013年1月-2014年12月来本院帕金森病专病门诊就诊的新余市渝水区154例PD患者。其中男94例，女60例；平均年龄为（66.81±18.00）岁；已婚140例，离婚/分居14例；受教育年限小学以下100例，初中以上5