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超声生物显微镜评价川芎嗪对大鼠颈总动脉损伤后内膜增生干预效果的研究影像医学与核医学(超声方向)专业论文
汕头大
汕头大学医学院临床型硕士研究生毕业论文
PAGE
PAGE VI
Abstract
Objective Evaluated the intervention effect of different dose tetramethylpyrazine in rat common carotid artery intimal hyperplasia from morphology and hemodynamics direction by using ultrasound biomicroscopy . Aimed to lay the foundation of exploring the mechanisms and targets of tetramethylpyrazine in the prevention of vascular restenosis in the further.
Methods 60 healthy male Sprague-Dawley rats were divided into 6 groups (n=10) : negative control group (C), Model group(M), tetramethylpyrazine group (T1,T2,T3) , and rosiglitazone positive control group(R). Except for group C , established the model of rat left carotid artery intimal hyperplasia by artery balloon injury. the rat common carotid artery 24 hours later, group T1 ,T2 and T3 were applied respectively in low , medium and high dose of tetramethylpyrazine hydrochloride injection by intraperitoneal injection once a day. Group R were gavaged with Rosiglitazone once a day. 21 days later, morphology and hemodynamics of each rat’s left common carotid artery were detected by using ultrasound biomicroscopy, including the inner diameter , intima morphology , wall thickness, peak systolic velocity , resistance index and pulsatility index.Finally prepare the histopathological specimens of the carotid artery and
measured the intima thickness, tunica media thickness and the ratio
of Intima-media thickness. Comparatived the biomicroscopy testing index and histopathologically determined datas of different group .Figured out the correlation of imageology and histopathology to summarize the effect of different doses tetramethylpyrazine intervention on vascular intimal hyperplasia.
Results (1 )Ultrasound biomicroscopy observed all rat’s common carotid artery Intima morphology , The intima of group C were smoothly , and the others were coarse and thickening , which of group M and group T3 thickening most obviously.For each measurement , comparison analysis results are as
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