恶性肿瘤患者外周血T淋巴细胞亚群的改变及其临床意义-医学免疫学专业论文.docxVIP

结 论 1．恶性肿瘤病人有细胞免疫功能紊乱和/或低下，表现为： +1．1 外周血淋巴细胞群中 CD3 + T 淋巴细胞比例下降； 3 41．2 外周血淋巴细胞群中 CD +CD 3 4 T 淋巴细胞比例下降； 3 81．3 外周血淋巴细胞群中 CD +CD 3 8 T 淋巴细胞比例升高； + + + +  + + + + +1．4 CD3 + CD4 T 淋巴细胞与 CD3 CD8 T 淋巴细胞比值（CD3 CD4 / CD3 CD8 比值）下降。 3 42．鼻咽癌组病人外周血淋巴细胞群中 CD +CD 3 4 T 淋巴细胞比 例及 CD3 CD +T 淋巴细胞与 CD + 4 3+ + + + 4 3 CD8 T 淋巴细胞比值（CD3 CD4 / CD3 CD8 比值）较其他肿瘤组病人低，其他肿瘤组病人之间无 差别,提示鼻咽癌的细胞免疫功能较为紊乱和/或低下。 +3．肿瘤病人中不同年龄、不同性别不影响外周血淋巴细胞群中 CD3 + T 淋巴细胞、CD +CD + T 3 4+ + + + + + + 3 4 淋巴细胞、CD3 CD8 T 淋巴细胞比例及 CD3 CD4 T 淋巴细胞与 CD3 CD8 T 淋巴细胞比值（CD3 CD4 / + + CD3 CD8 比值）的改变。 关键词 恶性肿瘤 ； T 淋巴细胞亚群 ； 细胞免疫； 流式细胞术 Alterations and Significance of T lymphocyte subsets in peripheral blood in patients with carcinoma Postgraduate: Wu Yinge Supervisor: Li Kangsheng Abstract Background and Objective In 2005, the Chinese Medical Department (CMD) carried out the investigation for the causes of death for the city inhabitant and the countryside inhabitant, the results indicated that cancer was the leading cause of death for the city inhabitant, while it ranked 3rd among the causes of death for rural dwellers. Cancer posts severe threat on people’s life and health. Although we have made considerable progress in the treatment of cancer these days, including improvements in surgery, radiation therapy and cytotoxic chemotherapy and so on, it is not entirely optimistic for patient to recover for cancer. In recent years, with the advances of basic theory and clinical research for cancer, more and more attention has been paid on the interactions between cancer and immunity. Cancer was not a simple disease process, and the immunity of anti-tumor was also an extremely complicated process which involved with a great deal of immunity mechanisms, cellular immunity severed as a pivotal role against the occurrence and development of cancer. Activated immune cell such as T lymphocyte, natural killer cell (NK) and macrophage cell directly killed targeted t