消脂康配方颗粒治疗非酒精性脂肪肝临床的研究.docVIP

消脂康配方颗粒治疗非酒精性脂肪肝临床的研究 　　摘要：目的 观察消脂康配方颗粒治疗非酒精性脂肪肝的临床疗效。方法 将90例非酒精性脂肪肝患者随机分为治疗组和对照组各45例，对照组在常规西医治疗的同时口服二甲双胍肠溶片，治疗组在常规西医治疗的同时给予消脂康配方颗粒口服，疗程均为3个月，观察2组患者治疗前后血脂、胰岛素抵抗情况，比较2组临床疗效。结果 治疗组临床显效率（35.5%）、总有效率（84.5%）及治疗后中医证候积分（13.78±3.6）均优于对照组（PO.05）。2组治疗后谷丙转氨酶、谷草转氨酶、三酰甘油、总胆固醇均较治疗前降低（P0.05，P0.01），组间总胆固醇、三酰甘油比较差异有统计学意义（P0.05），B超分度积分比较差异有统计学意义（P0.05），治疗组均优于对照组。2组治疗后空腹血糖、胰岛素抵抗指数均较治疗前降低（P0.05），治疗组空腹血糖优于对照组（P0.05）。结论 消脂康配方颗粒治疗非酒精性脂肪肝疗效显著。 　　关键词：消脂康配方颗粒；非酒精性脂肪肝；临床疗效 　　DOI：10.3969/j.issn.1005-5304.2015.08.007 　　中图分类号：R259.755 文献标识码：A 文章编号：1005-5304（2015）08-0022-04 　　Clinical Study on Xiaozhikang Formula Granules for the Treatment of Nonalcoholic Fatty Liver Disease LI Shi-jie， ZHAI Hong-wei （The Second Traditional Chinese Hospital of Taian City， Taian 271000， China） 　　Abstract：Objective To observe the clinical efficacy of Xiaozhikang Formula Granules for the treatment of nonalcoholic fatty liver disease. Methods Totally 90 patients with nonalcoholic fatty liver disease were randomly divided into control group and treatment group， 45 cases in each group. Patients in the control group were treated with conventional western treatment and oral metformin enteric-coated metformin hydrochloride， while patients in the treatment group were treated with Xiaozhikang Formula Granules on the basis of conventional western treatment for 3 months. Blood lipid and insulin resistance in the two groups before and after treatment were observed， and the clinical efficacy between the two groups was compared. Results Clinical excellence （35.5%）， total effective rate （84.5%） and TCM syndrome score （13.78 ± 3.6） after treatment of treatment group were better than those of control group （P0.05）. GPT， GOT， TG， and TC in both groups were lower after the treatment （P0.05， P0.01）. There existed statistical significance in TC and TG between the two groups after treatment （P0.05）. There existed statistical significance in B ultrasound index between the two groups after treatment （P0.05）， and the treatment group