姜黄生姜醇提物对幼龄S大鼠前列腺的作用.docVIP

姜黄生姜醇提物对幼龄SD大鼠前列腺的作用 ：杨家庆，张志华，胡英杰，张美义，朱宇同，李 国桥 】目的观察姜黄与生姜醇提物对幼龄SD大鼠前 列腺生长的影响。方法取姜黄与生姜各500g,粉碎混匀后 加70%乙醇回流提取制得醇提物;取体质量约50g的SD大鼠 随机分成正常对照组、阳性药物组、醇提物低、中、高剂 量组，每组13只。正常对照组及阳性药物组均按 20mL - kg-1体质量灌胃(ig)给予生理盐水(NS)，另阳性药 物组按lm g ? kg-1体质量皮下注射(sc)己焼雌酪，每周3 次;低、中、高剂量组按20mL ? kg-1体质量ig给予醇提物 连续3周。3周后，测定血清总酸性磷酸酶(TAP)水平，再 取睾丸、精囊腺、前列腺(腹叶、侧叶、背叶)分别称取湿 重，计算各指数。结果与正常对照组比较，醇提物中、高 剂量组的大鼠前列腺生长均受到明显抑制(P 关键词】姜 黄;生姜;幼龄大鼠；良性前列腺增生(BPH) Abstr act:Object iveToobser vethecombi nedeffects ofCurcumaafjuvenileS rcumaandGianoltogettndGingeron ofCurcumaa fjuvenileS rcumaandGi anoltogett ndGingeron pragueDawl nger500gre heethanole thegrowtho eyrats. Met spectively xtracts. SD fprostateo hodsTakeCu ，add70%eth ratswithbo dyweightabormalcontrethanolextoups, withl algroupand NSat20mLpe dyweightab ormalcontr ethanolext oups, withl algroupand NSat20mLpe tivemedici lbestrolth out50gwere olgroup, po ractsoflow 3ratsineac positiveme rkgbodywei negroupwer roughsubcu randomlydi sitivemedi -，mid-andh hgroup. Rat dicinegrou ght,andrat etreatedby taneousinj videdinton cinegroup, igh-dosegr sinthenorm pweregiven sintheposi diethylsti ectionatlm gperkgbody weightthre etimesawee k. Ratsinlo w-, mid- and high-doseg roupsweret reatedbyetctthroughiLperkgbodyloftotalacterminedan ostate (ven ratedandwencompariso and high-doseg roupsweret reatedbyet ctthroughi Lperkgbody loftotalac terminedan ostate (ven ratedandwe ncompariso nificantin ntragastri weight. Thr idphosphat dthetestis tral, later ightedforv nwiththeno hibitionwa cadministr eeweekslat ase (TAP)in ,seminalve alanddorsa iscerainde rmalcontro sobservedi hanolextra ationat20m er,theleve serumwasde sicleandpr 1)weresepa x.ResultsI 1group, sig nprostateg rowthinmid -andhigh-d osegroups (PKeywords: Curcuma: Gi nger; juven ilerats;be nignprosta tichyperpl asia(BPH) 良性前列腺增生(b enignprost atichyperp lasia, BPH)是困扰老年男性的常见疾病，以排尿困难、尿闭等为 主要临床特征。姜黄根茎中主要含挥发油类及姜黄素两大 类成分。姜黄素类为二苯基庚烃类成分，主要含姜黄素、 去甲氧基姜黄素和双去甲氧基姜黄素［1］。生姜的块茎主要 含挥发油类、姜辣素、二苯基庚烷［2］。杨磊等［3］的研究 表明姜黄素能抑制雄激素受体的表达，说明姜黄素具有类 雌激素的