子宫胎盘部位超常反应8例临床病理分析..docVIP

子宫胎盘部位超常反应8例临床病理分析 形态学，组织学特点、免疫组化标记 断，对临床治疗意义重大。［关键词］胎盘；滋养叶细胞; 关键词】胎盘；滋养叶细胞；病理 ［ ］目的：探讨子宫胎盘部位超常反应（EPS）的临 床病理特征，并讨论与其他易混淆的中间滋养叶细胞肿瘤及 瘤样病变的鉴别诊断、免疫组化特点。方法：收集我院2000 年至n年间诊断的EPS病变8例，观察和分析其临床和病 理组织学特点、预后分析及相关免疫组化标记。结果：EPS 组织学特征为以中间型为主的滋养细胞向蛻膜及平滑肌层 浸润，不破坏原有组织结构，不形成肿块，并保留部分胎盘 床特点。临床表现多有妊娠后及产后阴道出血，预后良好。 结论：EPS是一种较少见的与妊娠有关的滋养叶细胞病变， 是一种良性非肿瘤性病变，常导致产后大出血，仔细寻找EPS 有助于确定E PS 形态学，组织学特点、免疫组化标记 断，对临床治疗意义重大。 ［关键词］胎盘；滋养叶细胞; 病理 Ab stract : Ab stract : Objectives? calandclinicalfeat lacentalsite (EPS)a nosticcriteriaanddis. MethodsThepatho calandclinicalfeat lacentalsite (EPS)a nosticcriteriaandd is. MethodsThepatho munohistochemicalm cteristicsandprogn uresofexaggeratedp ndtoproposeitsdiag ifferentialdiagnos logicalfeatures,im arks,cl inicalchara osisof8caseswithEP SwerestudiedandTheeofEPSwasthattroph mediatetrophoblast odeciduaandmyometr ginalhistologicals royed,andplacental ed’ tbecomealump. Th almarksofEPS,HPL, w glypositive.Thepri tat ionofEPSwaspost dtheprognosiswasgo ionsEPSisakindofge sticdiseaseprimari ofpositivenottumor s,andoftencausethe edgreatly. Itsdiffe pendoncombininghis stochemicalfinding SwerestudiedandThe eofEPSwasthattroph mediatetrophoblast odeciduaandmyometr ginalhistologicals royed,andplacental ed’ tbecomealump. Th almarksofEPS,HPL, w glypositive.Thepri tat ionofEPSwaspost dtheprognosiswasgo ionsEPSisakindofge sticdiseaseprimari ofpositivenottumor s,andoftencausethe edgreatly. Itsdiffe pendoncombininghis stochemicalfinding res. Attentionsshou histologicalfeatur oblastsmainlyinter (IT),infitratedint iumlayers,whileori tructurewasnotdest sitefeaturesremain eimmunohistochemic erepositiveorstron maryclinicalpresen partumhemorrhagean odin5years. Conclus stationaltrophobla lyinvolvingisakind pathologicalchange postnatalperiodble rentialdiagnosisde tological,immunohi s,andclinicalfeatu ldbepaidtoEPSincas eswithpostpartumhe morrhage. Keywords： Placenta； Trophobl ast； Pathology 子宫胎盘部位超常反应（EPS）是一种比较少见的非肿瘤 性病变，1991年，WHO将其列入中间滋养叶细胞源性疾病。 但目前国内外对该病的诊断尚无统一标准，名称也不统一， 特别是与胎盘部位(pla