抗Jo―1抗体综合征临床剖析.docVIP

抗Jo―1抗体综合征临床剖析 　　【摘要】 目的：分析17例抗Jo-1抗体综合征病例的临床特点。方法：选取本院2008年1月1日-2015年12月31日收治的Jo-1抗体综合征17例患者的?R床资料进行回顾分析。对17例患者的一般资料、临床表现、实验检查及治疗方法进行研究，并对其进行统计学分析。结果：17位患者中包括女11例，男6例，女性与男性的比例为1.8∶1，年龄33～69岁，平均（52.21±18.42）岁，病程1个月～8年，平均（25.27±9.93）个月。初治13例，复发病例4例。临床表现包括：肌炎、多关节炎、间质性肺炎、发热、技工手、雷诺现象。间质性肺炎发生率为100%。结论：抗Jo-1抗体综合征患者临床多以多关节炎或肌炎起病，肌炎程度一般较轻。ILD在抗Jo-1抗体综合征中发生率高，为患者主要死因，该病恶性肿瘤伴发率低。 　　【关键词】 抗Jo-1抗体综合征； 临床分析； 肌炎； 皮肌炎； 间质性肺炎 　　Clinical Analysis of Anti-Jo-1 Antibody Syndrome/LIN Shu-huan，ZHENG Xiang-xiong.//Medical Innovation of China，2017，14（06）：044-047 　　【Abstract】 Objective：To analyze the clinical characteristics in 17 cases with anti-Jo-1 antibody syndrome.Method：The clinical data about 17 patients with anti-Jo-1 antibody syndrome in our hospital from January 1，2008 to December 31，2015 were reviewed.The clinical data，clinical manifestation，clinical examinations and treatment methods were investigated.Result：For 17 cases，there were 11 female cases and 6 male cases，the male/female ratio was 1.8∶1，the onset age ranged from 3 to 69 years old，the average age was（52.21±18.42）years old；the disease course was 1 month to 8 years；the average disease course was（25.27±9.93）month.There were 13 cured cases and 4 recurrent cases.The clinical characteristics included myositis，polyarthritis，interstitial pneumonia，fever，technical hand and Raynaud’s phenomenon.The incidence rate of interstitial pneumonia was 100%.Conclusion：Anti-Jo-1 antibody syndrome patients with arthritis or myositis onset myositis degree generally lighter.ILD anti-Jo-1 antibody syndrome in high incidence is the main cause of death in patients with low incidence of the disease associated with malignant tumor. 　　【Key words】 Anti-Jo-1 antibody syndrome； Clinical analysis； Myositis； Dermatomyositis； Interstitial pneumonia 　　First-author’s address：Fujian Medical University Union Hospital，Fuzhou 350001，China 　　doi：10.3969/j.issn.1674-4985.2017.06.012 　　随着近年来相关研究的不断深入，很多学者指出，若有患者体内的抗Jo-1抗体检查结果为阳性，则其会出现一组特别的症候群，在临床被称为Jo-1抗体