肩周炎患者推拿治疗前后血清IL8，IL32，IL18检测的临床意义.docVIP

肩周炎患者推拿治疗前后血清IL-8，IL-32，IL-18检测的临床意义 孙黎明(山东省荣成市屮医院 264300) 】目的探讨了肩周炎患者治疗前后血清IL-8, IL-32和IL-18水平的变化 及意义。方法应用放射免疫分析法和酶联法对31例肩周炎患者进行了推拿治 疗前后血清IL-8, IL-32和IL-18水平检测，并与35名正常健康人作比较。结果肩 周炎患者在推拿治疗前血清IL-8, IL-32和IL-18水平均非常显著地高于正常人(P 0.01),经推拿治疗2周后则与正常人比较无显著性差异(P〉0.05),且血淸IL-8 水平与IL-32, IL-18水平呈显著正相关(「=0.6118,0.4982, P0.01)。结论检测 血清IL-8, IL-32和IL-18水平的变化与疾病的发生发展密切相关，具有重要的临 床价值。 关键词】肩周炎推拿疗法IL-8 IL-32 IL-18 屮图分类号】R446 】A 】2095-1752 (2013) 26-0026-02 Clinical Significance of Weasuremeat of Changes of Serum IL-8, IL-32, IL-18 Levels after massage therapy in Patients With periarthritis of Shoulder Diseases Abstract】 Objective: To explore the Clinical Significance of Changes of Serum IL-8,IL-32,IL-18 levels after massage therapy in patients with periarthrits of Shoulder Diseases. Methods: Serum IL-8(with RIA) Serum IL-32,IL-18(with ELSA) levels were determined both before and after massage therapy in 31patients with periarthritis of shoulder diseases as well as in 35 controls. Results: Before massage therapy the Serum IL-8, IL-3 2 and IL-18 levels in the patients were significantly higher than those in controls(P0.01), after massage therapy for 2 weeks, the Serum IL-8,IL-32 and IL-18 in the patients were no ware difference from those in controls(P0.05), Serum IL-8 levels were positive correlated with Serum IL-32,IL-18 levels(r=0.6118,0.4982, P 0.01). Conclusions: Detection of Serum IL-8,IL-32 and IL-18 levels were closely related to the occurrence and development of the diseases also provides important value clinically. Key words】 periarthritis of shoulder Massage therapy lnterleukin-8(IL-8) lnterleukin-32(IL-32) lnterleukin-18(IL-18) 肩周炎为康复医学科的常见病多发病，其发病机理十分复杂，多数学者 认为与感染炎症反应有关［1】。IL-8为主要的炎性细胞因子，在疾病的发生和发展 中起重要作用［2】，IL-32在炎症中起放大作用［3］。IL-18在抗感染中起十分重要的 作用［4】。本文对肩周炎患者进行了推拿治疗前后血清IL-8, IL-32和IL-18进行检 测，现将所得的结果报告如下： 资料与方法 1.1临床一般资料 1.1.1病人组：31人(男21人，女10人)均为我院康复科经临床明确 诊断的肩周炎患者(包括体征、X线以及实验室的相关检测项0)，并排除类风 湿性关节炎等其他病症。 1.1.2正常人组：35人(男23人，女12人)，均为我院体检中心经健 康体检合格的正常人，无心、肝、肺、肾等重要脏器疾患，肝、肾