Inclinical muliti.centerclinicaltrial 18F.FLT
study,廿le about and18F.FDG
PET-CT from2005Mar witllsixmedical
imagingApr to 2007 centers95
patients.
finally,55 old,mean
patients(22women,33men,17—82years ageof53.3士17.1year)
wereenrolledin
this definite from
reseach.Everypatientgot diagnosispathological
orclose wasdeterminedvisualassessmentand
analysis follow-up.Tumoraluptake by
calculationofstandardized ofPETwereevaluated
uptakevalue(suv).Allimages by
five nuclearmedicine usedblindmethod.Totwo
experienced physician apparent
being
to onvision half
carry and asPETresultof
analyze quantitativeanalysisseparately
themFDGstandard
pharmaceutical,amongadoptsmalignantSUV2.5;Absorb2.0,
FLTstandardmalignantSUV1.35;Absorb1.0.
adopts
Result
we me 18F-FDG
got highest productivity(55%)andradiochemistrypurity(93%)
、析t110.2ml BMI、0.7mlacetonitrileandTATM
K2C03.0.3ml 25mg.
wecan the of with0.1ml
1M,130。and
get highestproductivity18F.FI』syntheses
30mg
precursor.
Wefound16 and39 lesions.Treatthe or
malignantbenign pathologicalfollow-up
resultsas of
the“goldenstandard”,the
sensitivity,specificity,accuracy
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