关于FDG和FLT的化学合成及其在肺内结节鉴别诊断中的相关性研究.pdf

关于FDG和FLT的化学合成及其在肺内结节鉴别诊断中的相关性研究.pdf

Inclinical muliti.centerclinicaltrial 18F.FLT study,廿le about and18F.FDG PET-CT from2005Mar witllsixmedical imagingApr to 2007 centers95 patients. finally,55 old,mean patients(22women,33men,17—82years ageof53.3士17.1year) wereenrolledin this definite from reseach.Everypatientgot diagnosispathological orclose wasdeterminedvisualassessmentand analysis follow-up.Tumoraluptake by calculationofstandardized ofPETwereevaluated uptakevalue(suv).Allimages by five nuclearmedicine usedblindmethod.Totwo experienced physician apparent being to onvision half carry and asPETresultof analyze quantitativeanalysisseparately themFDGstandard pharmaceutical,amongadoptsmalignantSUV2.5;Absorb2.0, FLTstandardmalignantSUV1.35;Absorb1.0. adopts Result we me 18F-FDG got highest productivity(55%)andradiochemistrypurity(93%) 、析t110.2ml BMI、0.7mlacetonitrileandTATM K2C03.0.3ml 25mg. wecan the of with0.1ml 1M,130。and get highestproductivity18F.FI』syntheses 30mg precursor. Wefound16 and39 lesions.Treatthe or malignantbenign pathologicalfollow-up resultsas of the“goldenstandard”,the sensitivity,specificity,accuracy

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