不同类型慢性荨麻疹与血管内皮生长因子及其相容性受体相关性分析.docxVIP

不同类型慢性尊麻疹与血管内皮生长因子及其相容性受体相关性分析 李文政于世荣 (新疆维吾尔自治区人民医院皮肤科 新疆 乌鲁木齐830001) 【摘 要】冃的：比较不同类型的慢性尊麻疹患者与血管内皮生长因子浓度 及其相容性受体(sVEGFRl和sVEGF2)Z间的相关性。方法：采用病例对照分析设 计，收集我院2012年1月至2014年12月收治的66例慢性尊麻疹患者(CU组)， 13例伴桥本氏甲状腺炎的慢性尊麻疹患者(CU /桥本组)，12例迟发性压力性尊麻 疹患者(DPU组)，并选取34例正常健康人群(对照组)，通过酶联免疫吸附试验 (ELISA)检测血清屮的VEGF及其受体的浓度，对比分析血管内皮生长因子及其相 容性受体和不同类型慢性尊麻疹Z间的关系。结果：在慢性尊麻疹组和健康对照 组屮VEGF浓度无特异性差异。然而，在CU/桥本组和DPU组VEGF浓度比其他 两组明显升高(Plt;0.05)。此外，在CU /桥本组的患者无论是缓解期还是活跃期， VEGF值均明显高于健康者，TSH值与VEGF浓度显著相关。sVEGFl和SVEGF2在 慢性尊麻疹组和健康组屮浓度相似。结论：VEGF浓度的增加可能引发伴随桥本 氏甲状腺炎的慢性尊麻疹。 【关键词】血管内皮生长因子；桥本氏甲状腺炎；慢性尊麻疹 【中图分类号】R758.24 【文献标识码】A 【文章编号】1004-6194 (2015) 01-0152-02 【Abstract] Methods:A case-c ontrol study was con ducted on 66 patie nts with CU ,13patients with CU with concomitant euthyroid Hashimotorsquo;s thyroiditis (CU/Hashimoto) 12 patients with delayed pressure urticaria(DPU) and 34 healthy subjects which were collected from January 2012 to December 2014 in our hospital.The concentration of serum VEGF and its receptors are detected by enzyme-linked immunosorbent assay (ELISA), comparative analysis the relationship between the different types of chronic urticaria and vascular endothelial growth factor with its receptors.Result: There was no specificity differences in VEGF concentration between chronic urticaria group and healthy subject group」n contrast, VEGF concentration significantly higher in the CU/hashimoto and DPU group than the other two groups」n addition, whether the CU/hashimoto patients in remission or active, VEGF concentration were sigrdficantly higher than the healthy subjects, TSH values sign讦icantly associated with VEGF concentration .sVEGFl and sVEGF2 concentration in chronic urticaria group and healthy group are similar.Conclusion:The findings suggest that the in crease of VEGF conce ntrati on may lead to chr onic urticaria itself a nd the accompa nying Hashimotorsquo;s thyroiditis. 【Key Words] VEGF; Hashimotorsquo;s thyroiditis; Chronic urticaria 慢性寻麻疹是一种临床上常见的反复发作的过敏性疾病，是各种因素致使皮 肤、黏膜、血管发生暂时性炎性充血与组织内水肿，