两种方法测定血液透析浓缩液中氯离子的含量探究.pdfVIP

第47卷第3期 应 用 化 工 Vol.47 No.3 2018年3月 Applied Chemical Industry Mar.2018 分析测试 两种方法测定血液透析浓缩液中 氯离子的含量研究 邹敏,彭东明,彭俊英,李鸣,王福东 (湖南中医药大学 药学院,湖南 长沙 410208) 摘 要:采用离子色谱法与离子计法测定血液透析浓缩液中氯离子的含量。 以SH离子柱为色谱柱,以2 mmol/ L Na CO 和10 mmol/ L NaHCO 为流动相,流速1.5 mL/ min,进样量为25 μL,检测器为电导检测器。 离子色谱法与 2 3 3 离子计法分别在5~25 mg/ L、600~3000 mg/ L范围内呈良好的线性关系,相关系数均大于0.999;平均加标回收率 分别为99.67%,97.01%,RSD均小于2.0%。 结果表明,两种方法均能快速、准确的测定血液透析浓缩液中氯离子 的含量,且两者的测定结果无显著性差异。 关键词:离子色谱法;离子计法;氯离子 + 中图分类号:TQ463 .3;R917 文献标识码:A 文章编号:1671-3206(2018)03-0608-03 Comparison of two methods for the determination of chloride in hemodialysis concentrate ZOUMin,PENGDong-ming,PENGJun-ying,LI Ming,WANGFu-dong (College of Pharmacy,Hunan University of Chinese Medicine,Changsha410208,China) Abstract:To determinethecontentof chlorideinhemodialysisconcentratebyionchromatogramphyorion meter.Ion chromatography was performed with SH ion column under 2 mmol/ L Na CO and 10 mmol/ L 2 3 NaHCO asthe mobile phase at aflow rate of 1.5 mL/ min.The injection volumewas25 μL and the de-3 tection was conductivity detector.Determination of chloride in hemodialysis concentrate all showed good linear relationshipbyionchromatogramphy attherangeof5~25 mg/ Lorionmeterattherangeof600~ 3000 mg/ L,correlation coefficient “r” wasall above0.999.Therate of average addition standardrecov- ery was99.67% and97.01% respectively,and the RSD was all less than 2.0%.The results show that both methods can determine the content of chloride i