大鼠急性心肌缺血再灌注损伤与解偶联蛋白2表达的关系.pdfVIP

The of Protein2inacute ExpressionUncoupling myocardial ofratheart Ischemic—reperfusioninjury PostgraduateGuoQiuYing TutorProfessor Wei YunFeng Abstract 0bjeetives：Acute ofheartcauses myocardialIschemic—reperfusioninjury ofreactive resultsinaserialof increasingproduction oxygenspecies(ROS)and such and damagesas：lipidperoxidation，DNA injuryapoptosis hasbeen that Protein in reportedUncoupling2(UCP2)is widespread inner membraneoftissue c,ndecreasethe of includingcadiocyte，and ROS．The isto the of inacute UCPz presentexperimentinvestigateexpression ratheart．Methods：24SDratswere myocardialischemic—reperfusion injured dividedintothree at animalsofeach random，8 groups hour o groupof(Shamgroup)，2 injury 6hour r6h left group)；andpost—ischemic—reperfusioninjurygroupgroup)．The anterior occluded2mm coronary fromits with descendingartery(LAD)was