胃癌患者手术治疗前后血清IGFI、HCY和CA724水平检测的临床意义.docxVIP

胃癌患者手术治疗前后血清IGF-I、HCY和CA724水平检测的 临床意义 张守兵 (江苏省连云港市赣榆县圣安医院222200) 【摘要】目的:探讨了胃癌患者手术治疗前后血清IGF-k HCY和CA724水平 的变化及临床意义。方法：应用放射免疫分析法和酶联法对31例胃癌患者进行 了手术治疗前后血清IGF?I、HCY和CA724水平检测，并与35名正常健康人作比 较。结果：胃癌患者在手术治疗前血清IGF-K HCY和CA724水平均非常显著地 高于正常人组(p0.01),经手术治疗6个月后则与正常人比较无显著性差异(p 0.05),且血清IGF-I水平与HCY、CA724水平呈显著正相关(r二0.5926,0.6021, p0.01)o结论：检测胃癌患者治疗前后血清IGF-L HCY和CA724水平的变化对 观察病情和预后判定均有重要的临床价值。 【关键词】胃癌 胰岛素生长因子一I同型半胱氨酸 糖类抗原72?4 【中图分类号】R735.2 【文献标识码】A 【文章编号】2095-1752 (2014) 12-0055-02 Clinical Significanee of Weasurement of changes of Serum IGF-I、HCY and CA72-4 Levels after operation in patients With gastric cancer. Jiangsu Guanyun County Sen?An hospital Zhang Shoubing [Abstract] Objective To explore The clinical Significanee of measurement of Changes of Serum IGF-I、 HCY and CA724 levels after operation in patients With gastric cancer. Methods:Serum IGF-ICA724 (With RIA), and Serum HCY (With ELISA) levels were determined in 31 patients With gastric cancer both before and after operation as well as in 35 controls. Results Before operation, the Serum IGF-I、HCY and CA724 levels were Sign讦icantly higher in the patients than those in the Controls (p0.01) .After operation for 6 months,the levels were not Significantly different from those in Controls (p0.05).Serum IGF-I levels were positively correlated With Serum HCY、CA724 levels (r二0.5926、0.6021, p 0.01) .Conclusions Detection of Serum IGF-L HCY and CA724 levels after operati on might be of prog no Stic in prota nee in patie nts With gastric can cer. 【Key words］ gastric cancer insulin-like growth factor-l(IGF-l) homocysteine(HCY) Carbohydrate antigen72-4(CA72-4) 文献证实⑴：IGF?I是--种由多种肿瘤细胞产生和分泌的调控因子，在恶性 肿瘤的发生和发展中起着举足轻重的作用。HCY检测对消化道肿瘤的检测具有一 定的临床价值［2］。CA72-4是一种广谱的肿瘤标志物，对胃癌的诊断具有较高的 敏感性⑶。 国内尚少见有胃癌患者手术治疗前后血清IGF-K HCY和CA724水平联合检测的 报道，为此，我们进行了探讨，现将我们的结果报告如下： 1资料与方法 1.1临床一般资料 1.1.1病人组31人(男25、女6),均为我院经临床明确诊断的胃癌患者(包 括体征、顿透、胃镜和部分实验室相关的检测报告，最后经手术后病理切片证实)。 1.1.2正常人组35人(男28、女7),均为我院体检中心经健康体检合格的 正常人，无心、肝、肺、肾等重要脏器疾患，肝、肾功能试验正常，家庭中无肿 瘤史。 1.2方法 1.2.1血清IGF-L CA724