急性白血病诱导化疗中血清粒细胞集落刺激因子水平的变化及意义-内科学(血液病)专业论文.docxVIP

中文摘要急性白血病诱导化疗中血清粒细胞集落刺激因子 中文摘要 急性白血病诱导化疗中血清粒细胞集落刺激因子 水平的变化及意义 摘 要 目的：了解急性白血病患者在诱导化疗前后血清粒 细胞集落刺激因子(G．CSF)水平与外周血中性粒细胞 数值间关系及临床意义。 方法：采用酶联免疫吸附法(ELISA法)连续观察 3 l例单纯化疗及并用G．CSF患者化疗前后血清中G—CSF 及中性粒细胞数值。 f结果：(1)无感染时，急性白血病患者化疗前血清 G．CSF水平平均吸光度值为0．05±0．06，略高于正常对 照平均吸光度值(O．05)(JD0．05)。(2)单纯化疗患者， 化疗后血清中G—CSF水平动态改变表现为以下4种类 型：双峰、单峰、v型、波状下降，且与外周血中性粒 细胞数值相关。(3)化疗后并用G．CSF者，血清中G—CSF 水平(平均吸光度值为0．27±0．04)及中性粒细胞值明 显增高(2．844-1．94×109／L)，与单用化疗组相比，前者 中性粒细胞恢复时间明显缩短／∥ 结论：(1)动态观察白血病患者化疗后血清中G．CSF 水平，有助于估计骨髓抑制程度，指导临床上合理应用 G—CSF。(2)化疗后并用G．CSF可明显缩短中性粒细胞 减少时间和感染率。 关键词：急性白血病，粒细胞集落刺激因子，中性 粒细胞。 英文摘要The 英文摘要 The clinical significance and change of granulocyte colony-stimulating factor in serum during induction treatment of acute leukemia· ABSTRACT ohjective：To investigate the clinical significance and the relationship between the serum G—CSF 1evels and neutrophil counts in patients with acute 1eukemia． Methods：The consecutive changes of G—CSF levels were assayed by ELISA and neutrophil counts by Automatic hemocytometer in 3 l cases of acute leukemia receiving chemotherapy with or without administration of G—CSF． Results：(1)Before chemotherapy G—CSF levels (OD=0．05±0．06)were higher in acute leukemia patients． Than that in nornlal control(oDO．05)(P0．05)(2)Four patterns were observed in consecutive change of serum G— CSF levels in 1 9 cases receiving chemotherapy alone：curve with double peaks、single peak、V type and declining type． differen patterns of G—CSF change were accompanied with different changes of neu仃ophil counts．(3)Both serum G— CSF levels(OD=O．27-+-0．04)and neutrophil counts(2．84+ 1．94×l 09／L)were elevated significantly in 11 cases receiving G—CSF after chemotherapy． (4) Compared with chemotherapy alone，the time required for neutrophil count to 2 英文摘要reach 英文摘要 reach a level more than 1．5×1 09／L was significantly shorter in patients receiving chemotherapy followed by G—CSF administration． Conclusion：(1)The observation of the changes of serum G—CSF levels is helpful in judging myelosupression and