汕头大学医学院药理学精品课程 DRUGS FOR CHF.pptVIP

Drugs for Congestive Heart Failure BACKGROUND DEFINITION: The inability of heart to meet the needs of peripheral systems. PATHOGENY: myocardium contraction heart load SYMPTOMS: weakness, fatigue and dyspnea, cyanosis, edema . Change of myocardial structure in CHF Apoptosis Extracellular matrix(ECM) fibrosis Myocardial hypertrophy and remodeling. Change of myocardial function in CHF Systolic dysfunction actin-troponin-tropomyosin system ATP Ca-excitation-contraction-coupling Diastolic dysfunction compliance Change of neural-endocrine system in CHF sympa