基于支持向量机的蛋白质网络重要节点分类方法研究.docVIP

摘要 classification method whose research production are relative abundance in order to our new predicting method, TC_SVM, of essential proteins in network level which provides a new way for researching identification of essential proteins. Experiment results in this paper indicate that the performance of TC_SVM is better than classical ten reference topological centrality measures generally according to comparative analyses in statistic indexes, especially its advantages are obvious of indexes of F-measure and AUC who are to measure classified performance of prediction comprehensively. Through the performance analysis and comparison, the better performance of TC_SVM indicates it is feasible to fuse multi classical topological centrality measures rationally, and more to enrich relevant researches by means of construction for new identifications of essential proteins based on classification idea. To convert sorting and screening mode of the existing essential protein identification methods to a classification task in the feature space through the fusion of multi centrality measures proposed in this paper extends the research field of essential protein identification and improves the accuracy of prediction, and moreover provides a new valuable bioinformatics method for identification of essential proteins. KEYWORDS protein interaction network, essential protein, topological centrality measure, imbalance classification, support vector machine III 万方数据 绪论 第 1 章 绪论 在所有生命活动中，蛋白质分子间的相互作用是必不可少的，它是细胞进行一切 代谢活动的基础。生物体内所有蛋白质间的相互作用被称为蛋白质相互作用网络 （Protein- Protein Interaction Network) , 简称 PPI 网络。生命过程，如细胞的代谢、 信号传导以及基因表达调控等，都是通过蛋白质相互作用或蛋白质与 DNA 的相互作 用得以实现的。于是生命科学的研究热点逐渐从基因组学转移到蛋白质组学，特别是 对蛋白质网络的研究。 课题研究的重要性 蛋白质是构成一切细胞和组织结构必不可少的成分，它是生理功能的执行者，是 生命活动最重要的物质基础。相关实验表明，不同的蛋白质对生命活动的重要性是有 差异的，如按照功能上的重要性，可将蛋白质大致分为关键蛋白质(essential proteins) 和非关键蛋白质(non essential proteins)两类。目前关于关键蛋白质仍没有精确定义， 一般地认为经过对应基因的敲出使得某个蛋白质不能产生，由此相关生物组织的生物 功能不能正常执行，从而致其死亡或病变，则该蛋白质对于该生物组织的存活具有关 键性。从已有生物实验结果可知，关键蛋白质应该对于生物组织的存