利水化瘀膏敷脐治疗缺血性脑卒中急性期的临床与实验研究-中医内科学专业论文.docxVIP

提 提 要 目的：运用中医理论和现代医学理论，探讨利水化瘀啻敷脐治疗缺血性脑卒巾急 性期的临床效果及作用机理。方法：选择确诊为缺血性脑卒中急性期的病人60例， 随机分为两组，治疗组与对照组分别为30例，两组均给予20％甘露醇与曲克芦丁静 脉点滴，治疗组给予自拟利水化瘀膏敷脐治疗，对照组为中药空白对照，15天为1 个疗程。治疗1个疗程后，观察临床疗效与神经功能缺损评分情况以及对血脂、血液 流变学、MCA啦流动力学、甲皱微循环等方面的影响。实验研究部分则观察该药刑 大鼠脑含水量、血栓形成、血小板聚集、软脑膜微循环及血浆TXB2、6-Keto．PGFl。 等指标的影响。结果：两组愈显率分别为73．3％、46 7％，有效率分别为96．7％、93．3％， 有显著差异(_j，0．05)。治疗组在改善血脂、MCA血流动力学参数、血液流变学指 标及甲皱微循环方面明显优于对照组。动物实验结果表明，利水化瘀膏敷脐能减轻脑 水肿，抗血小板聚集、抗血栓形成，改善软脑膜微循环，降低TXB2／6一Keto—PGFl。比 值。结论：利水化瘀膏敷脐治疗缺血性脑卒中急性期安全效佳。 关键词缺m性脑卒中急性期；利水化瘀膏；脐疗 Clinical Clinical and Experimental Study on Tt‘eating the Acute Period of Cerebral Ischemic Stroke by Smearing Lishuihuayu Ointment in Navel Speciality： Internal Medicine of TCM’Clinical study on Nerve System Disease Author： Zheng shiwen Tutor：Hu zhiqiang Abstraet Objeetive：Based on Chinese and Modern medicine theory to explore the clinical effect and mechanism of treating the acute period of Cerebral Ischemic Stroke by smearing Lishuihuayu Ointment in Navel．Methods：Choose 60 patients whose definite diagnosis is Cerebral Ischemic Stroke，and divide them randomly into treatment group and contrast group，every group has 30 cases．The treatment group is treated by Lishuihuayu Ointment， Qukeluding and 20％Mannit01．The contrast group is treated without Lishuihuayu Ointment．A course oftreatment is 15 days．After one course oftreatment，observe clinical effect，nerve function defection，and the effects of lipid，blood rheology，MCA blood flow dynamics，microcirculation of nail，etc．The animal experimental study observes the indexes below：water content of brain，thrombus formation， blood platelet gathering，microcirculation of brain，the value of TXB2 and 6-Keto—PGF 1 a in plasma． Results：The remarkably effective rate in the treatment group reached 73．3％and the total effective rate reached 96．7％．while in the contrast group．the remaNably effective rate is only 46．7％．with a total effective rate of 93．3％．There is a remarkable difference between the two groups⑦O．05)．In the aspects of improving