利拉鲁肽对体外诱导的非酒精性脂肪肝细胞内质网应激的作用-内科学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要··························································································································1 英文摘要··························································································································3 英文缩写··························································································································6 研究论文 利拉鲁肽对体外诱导非酒精性脂肪肝细胞内质网应激的作用 前言··························································································································7 材料与方法··························································································································10 结果··························································································································22 附图··························································································································24 附表··························································································································27 讨论··························································································································29 结论··························································································································32 参考文献··························································································································33 综述 GLP-1 及其类似物在 NAFLD 治疗中作用的进展······································35 致谢··························································································································45 个人简历··························································································································46 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 利拉鲁肽对体外诱导的非酒精性脂肪肝细胞 内质网应激的作用 摘 要 目的: 通过观察胰高血糖素样肽-1（GLP-1）受体激动剂利拉鲁肽干 预 治 疗 体 外 诱 导 的 非 酒 精 性 脂 肪 肝 细 胞 模 型 的 内 质 网 应 激 相 关 指 标 GRP78 蛋白表达、ATF6 核蛋白水平和 caspase12 的变化，探讨利拉鲁肽 对 NAFLD 肝细胞抗