外泌体作为中药载体的研究进展-药学学报.PDF

外泌体作为中药载体的研究进展 1 2 2* 2 2 袁鹏 ，郭晓辰 ，张军平 ，吕仕超 ，朱亚萍 （天津中医药大学1.研究生院，2.第一附属医院，天津 300193 ） 摘要：外泌体作为新型的细胞间信息交流的载体，以其在人体内广泛分布性、 非免疫性与靶向性，被认为是天然的药物载体。中药能通过多靶点、多途径起到 对疾病的防治作用，但其制剂品种相对单一，存在有效成分溶解度不高、生物利 用度低等问题，限制了药 的更好发挥。而利用外泌体这种新型载药途径，能更 好地将有效成分递送至靶细胞。本文就外泌体生物学特征及其作为中药药物载体 的研究进展进行综述。 关键词：外泌体；药物载体；中草药；纳米技术；靶向性；生物有 性；难 溶型药物 中图分类号：R943 文献标识码：A 文章编号: 0513-4870 （2017） Research progress of the exosomes as drug delivery vehicles of Chinese herbal drugs 1 2 2* 2 2 YUAN Peng , GUO Xiao-chen , ZHANG Jun-ping , LV Shi-chao , ZHU Ya-ping (1. Graduate School, 2. The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) Abstract: As a new carrier of intercellular information exchange, the exosomes is widely regarded as a natural drug carrier for its extensive distribution, non-immunity and targeting in human body. Chinese herbal drugs through multiple targets and pathways play a role in the prevention and treatment of diseases, but the preparation of varieties is relatively simple, there is low solubility of its effective ingredients and low bioavailability, limiting the efficacy of better play. Using the new 收稿日期：2017-06-07；修回日期：2017-07-03 基金项目:国家自然科学基金资助项目；第二批国家“万人计划”百 千万工程领军人才资助. 通讯作者Tel: 86-22 E-mail: tjzhtcm@163.com drug delivery pathway of the exosomes, it is better to deliver the effective components to target cells. In this review, we reviewed the biological characteristics of exosomes and its progress as a carrier of Chinese herbal drugs. Key words: exosome; drug carrier; Chinese herbal drug; nanotechnology; targeting; bioavailability; water-insoluble drug 传统中医药具有完整的理论体系、独特的诊疗方式及 好的临床疗 ，长期 为祖国人民的健康保驾护航，但其