成人与青少年艾滋病的ART.pptVIP

* * * * * * In summary, antiretroviral therapy can significantly reduce morbidity and mortality related to HIV. However, for therapy to be effective, antiretroviral agents must be used in combination and must achieve a sustained decrease in viral load to below detectable levels. Decisions about antiretroviral therapy are complex and require consideration of potential adverse effects, drug interactions, resistance issues and the need for proper adherence. 脂代谢障碍的处理 改变生活方式：饮食，锻炼 换药或停药：将D4T换成AZT，PI 替换成NNRTI 药物：降糖药，降脂药 总 结 ART能减少HIV相关疾病的死亡率 ART必须三种药物联合使用 成功的ART取决于医生，病人，药物，病毒等四个方面的因素 及时和合理处理药物副作用，是确保ART成功的关键因素之一 替换单一药物对于处理药物毒性是合适的，但对于方案失败则不合适 决定换药或采用一组新的治疗药物，应该由该领域有丰富临床经验的医师决定 　　 谢　谢 * * - Baseline demographics were similar - CDC events were ABC IDV A 71% 73% B 21% 18% C 2% 4% Missing 6% 5% - age 35.6 36.1 - risk factors homosexual 60% 55% heterosexual 26% 28% IVDA 11% 13% transfusion 1% 3% occupational Exposure 0 1%(n=2) other 2% 1% * * * CD4：210，可以治疗。每年下降超过30%要治疗 * * * 仍然 * * * * Slide #10: Challenges to Successful HIV Depend on Drug Tolerability This Venn diagram illustrates the four interrelated components that play a role in determining successful outcomes with antiretroviral therapy and therefore should be addressed when initiating treatment. ? Designing a general strategy for interventions specific to each of these components right from the beginning of treatment is a key factor in the overall success of anti-HIV therapy. * Toxicity — the frequency and severity of side effects — of antiretroviral drugs is the number one reported reason for discontinuation of therapy. ? These results are based on 862 antiretroviral-na?ve subjects who participated in The Italian Cohort of Antiretroviral-Na?ve Patients (ICONA) study (March 1997 through May 1999).1 This cohort comprises patients who began HAART at the time of study enrollment. ? A total of 36% of patients discontinued from the study. The pie chart shows that of those di