食源性致病菌诱导细胞凋亡机理研究进展.PDF

234 2014, Vol.35, No.05 食品科学 ※专题论述 食源性致病菌诱导细胞凋亡机理研究进展 张 超，陈国薇，杨玉萍，吴淑燕，刘 箐* （上海理工大学医疗器械与食品学院，上海 200093 ） 摘  要：细胞凋亡是机体为清理衰老、受损的细胞，维持内环境稳定、确保机体健康而采取的一种有序性 “自杀方 式”。食源性致病菌进入机体后可通过诱导宿主细胞凋亡以逃离宿主的免疫清除，保证自身生存进而得以在机体内 扩散的生存策略。近年来研究表明，食源性致病菌的毒力因子在致病菌诱导宿主细胞凋亡过程中起到非常重要的作 用，许多致病菌通过产生相应的毒力因子与凋亡调控因子相结合，引起细胞凋亡的级联反应。本文主要从致病菌毒 力因子对凋亡信号通路的影响和调控方面来阐述食源性致病菌诱导细胞凋亡的机理研究进展。 关键词：食源性致病菌；细胞凋亡；毒力因子 Research Progress in the Mechanisms of Apoptosis Induced by Foodborne Pathogens * ZHANG Chao, CHEN Guo-wei, YANG Yu-ping, WU Shu-yan, LIU Qing (School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China) Abstract: Apoptosis is a way of “suicide” used by organisms to clean up the aging and damaged cells, to maintain the cellular homeostasis and to ensure the health of the body. Recent studies have shown that the virulence factors of foodborne pathogens play a vital role in inducing apoptosis in their host cells. After entering the body, the foodborne pathogens can escape the host immune clearance by inducing apoptosis in host cells to ensure their own survive and spread in the host body. Many pathogens produce virulence factors, which combine with the apoptotic regulators in host cells to induce apoptosis. This review provides a brief overview of the mechanisms of apoptosis induced by foodborne pathogens from the aspects of the regulation and effect of apoptosis signaling pathway caused by the pathogen-derived virulence factors Key words: foodborne pathogens; apoptosis; virulence factors 中图分类号：Q932 文献标志码：A 文章编号：1002-6630 （20 14 ）05-0234-05 doi:10.7506/spkx 1002-6630-20 1405046 流行病学监测显示，近十年来