第二章 药物化学合成工艺与化学制药反应器.ppt

普朗特数: ?g—流体热导率 Prandtl number: ?g -fluid thermal conductivity 有效扩散的Peclet数 Schmidt数 Dm– 气相组分的分子扩散系数 Peclet number of effective diffusion Schmidt number Dm-diffusion coefficient of the gaseous components 在固定床反应器一维模型中，可以认为床层径向温度是均匀的，用床层平均温度Tm与壁温Tw之差来定义传热速率： In the one-dimensional model of a fixed bed reactor, the bed radial temperature can be considered uniform. Using the difference between the average temperature of bed Tm and the wall temperature Tw to define heat transfer rate: 固定床反应器二维模型中则需要考虑床层的径向温度分布，传热速率以靠近壁面处流体温度TR与壁温之差来定义： In a two-dimensional model of fixed-bed reactor, the radial temperature distribution needs to be considered. The heat transfer rate is defined based on the difference between the fluid temperature near the wall TR and the wall temperature: 2.2.2.3、固定床反应器的参数敏感性 固定床反应器的参数敏感性是指某些操作参数的轻微变化对于反应器内温度或浓度的影响程度。 在强放热反应的列管式固定床反应器中，热点温度往往随操作条件的微小变化而发生显著变化，甚至影响反应器的安全操作。 2.2.2.3 Fixed-bed reactor parameter sensitivity ??? The sensitivity of the parameters in the fixed bed reactor is the effect of some slight variations of operating parameters on the reactor temperature or concentration. ??? In tube fixed-bed reactor of strong exothermic reaction, the hot spot temperature often has a significant change with small changes in operating conditions, and even affects the safe operation of the reactor. 参数敏感性的研究对于反应器的设计和操作都具有重要意义。 一般来说，不应在敏感区及其附近区域操作反应器。因此进行详细的设计、计算之前需要选择合适的条件和反应器的尺寸，以限制热点温度和避免反应器对参数变化过程敏感。 Parameter sensitivity study has important implications for reactor design and operation. ??? Typically, the reactor should not be operated in the sensitive area and its vicinity. Therefore,, you need to choose the right conditions and the size of the reactor prior to the detailed design and calculation, in order to limit the hot reactor temperature and avoid the reactor be sensitive to changing process parameters. 近年来,非线性理论的发展为反应器的非线性分析奠定了基础. 分岔理论、混沌理论可用于分析反应器如固定床的多定态行