比阿培南治疗复发性尿路感染临床价值探究.docxVIP

比阿培南治疗复发性尿路感染临床价值探 ［摘要］目的探讨比阿培南治疗复发性尿路感染 的临床疗效及其安全性。方法将84例复发性尿路感染患者 随机分为两组，对照组给予常规药物治疗，观察组在此基础 上加用比阿培南治疗。结果观察组显效率显著高于对照 组。观察组的症状消失时间显著低于对照组。观察组的复发 率显著低于对照组。观察组的不良反应发生率显著低于对照 组，观察组治疗后的血免疫球蛋白、血CRP等指标较治疗前 显著改善，且显著优于对照组。治疗后两组患者的外周T淋 巴细胞群均得到显著改善，但观察组的效果优于对照组。结 论比阿培南治疗复发性尿路感染起效快，疗效确切。 ［关键词］比阿培南；尿路感染；疗效；不良反应 ［中图分类号］R978. 17 ［文献标识码］B ［文章编号］ 1673-9701 (2013) 36-0048-03 Study on the clinical value of biapenem for treating recurrent urethral infection GE Huayingl CHEN Feng2 XU Qingkang2 SHEN Weihua2 SHI Xinyan3 1.The Endocrinologist Unit of th First People， s Hospital of Hangzhou City, Hangzhou 310006, China； 2. The Urinary Surgery of Armed Police Corps of Jiaxing Hosp it al, Jiaxing 314000, China； 3. The Urinary Surgery of the First People， s Hospital of Hangzhou City, Hangzhou 310022, China [Abstroct] Objective To explore the clinical effects and safety of biapenem for recurrent urethral infec tion (UTI)? Met hods A total of 84 patients with recurrent UTI were randomly divided into two groups? The control group was treated with routine drugs, while biapenem was added in observation group based on control group. Results The markedly effective rate in observation group was significantly higher than in control group, while disappearance time of synmp to ms, recurrent rate and incidence were markedly lower than in control group. Immunoglobulin and CRP in observation group after treatment obviously improved prior to treatment before, and superior to control group? After treatment , peripheral T lymphocyte subsets were ameliorated in two groups , and the effect in observation group was superior to control group. Conclusion In the treatment of recurrent UTI, biapenem quickly exerts a definite effect. [Key words] Biapenem ； Urethral infection ； Efficiency； Adverse reactions 复发性尿路感染是泌尿科常见的感染性疾病，临床定义 为指6个月内发作不少于2次或1年内发作不少于3次的尿 路感染[1],尤其多发于女性，据相关统计发现大约70%的女 性在一生中都曾患过复发性尿路感染[2] o男女患病比例约 为1：8[3],且伴有尿路结石、肾积水等并发症，过度劳累 或情志刺激均可诱发或加重尿路感染，目前主要采用抗菌药 物治疗，但治疗疗程周期长、容易复发，很难治愈，复发性 尿路感染晚期可造成慢性肾炎、肾功能