神经节苷脂对低出生体重儿神经行为影响的研究.docVIP

神经节苷脂对低出生体重儿神经行为影响的研究 第34卷 4102010年第6期 黑龙江医学 HEIL0NGJIANGMEDICALJOURNAL Vo1.34,No.6 JufL2010 神经节苷脂对低出生体重JL经行为影响的研究 吴春燕,白莉,王伟烈,李锦兰,牛庆玲 (大庆油田总医院儿科,黑龙江大庆163001) 摘要:目的探讨神经节苷脂对低出生体重儿(LBW)神经行为的影响.方法将单胎LBW72例随机 分为治疗组42例和对照组30例.所有患儿在综合治疗各项并发症,给予营养指导及早期干预基础上,治 疗组在生后第3d给予GM1静脉点滴,10d为1个疗程,休息20d,共进行2～5个疗程.在患儿6个月,12 个月时,采用Gesell量表进行神经发育评价.结果6个月时,治疗组DQ分值均高于对照组,各能区分值 比较:大运动,社会适应能区两组差异有显着性意义(Plt;0.05),而精细运动,语言,个人一社会能区两组差 异无显着性意义(Pgt;0.05);12个月时,治疗组5大能区DQ分值均高于对照组,各能区干预效果显着,尤 其大运动,精细运动能区两组差异有非常显着性意义(Plt;0.01),而其他能区两组差异具有显着性意义(P lt;0.05).结论神经节苷脂能促进低出生体重儿的神经行为发育,可预防和降低神经系统后遗症的发生, 改善预后. 关键词:低出生体重儿;神经节苷脂;神经行为发育 doi:10.3969/j.issn.1004—5775.2010.06.004 学科分类代码:320.34中图分类号:R748文献标识码:A Neur0behavi0rEffectofGM一1onLBWInfants WUChun—yan,BAILi,WANGWei—lie,eta1. (DepartmentofPediatrics,TheGeneralHospitalofDaqingOilField,Daqing163001,CHINA) Abstract:ObjectiveTostudytheneurobehavioreffectofGM—IonLBWinfants.Methods72casesofsingle fetusofLBWwerediviedintotreatmentgroup(42cases)andcontrolgroup(30cases)randomly.Onthebasis treatmentofcomplicatingdisease,nutritionguidanceandearlyintervention,GM一1wasgivenbyintravenousdrip inthetreatmentgroup3rddaysafterbirth,and10daysasonecourseoftreatment,20daysrest,about2—5 courseweredoneinal1.Whentheneonateswere6monthsoldand12monthsoldrespectivelyuseGesellscaleto evaluateAssessmentofneutraldevelopmentwereperformedbyGesellscalewhen6monthsand12months aged.ResultsTheDQscoreintreatmentgroupwashigherthancontrolgroupwhensixmonthsaged.Thescores ofgrossmovementandsocialadjustmentabilityhaveobviouslydifferencebetweentwogroups(Plt;0.05).Howev- er,infinemovement,language,individualandsocietyabilities,therehasnoobviouslysignificance(Pgt;0.05). When12monthsold,theDQscoresinfivemainattributeswerehigherthanthatincontrolgroup.Theintervention effectsineveryattributewereobviously,especiallythedifferencesingrossmovementandfinemovement(Plt; 0.O1).Therehaveobvioussignificanceintheothertwoattributes(Plt;0.05).ConclusionGM一1cannotonly improveneurobehaviordevelopmentofLBWinfants,butalsopreven