SGLT-2抑制剂对2型糖尿病患者大血管病变危险因素影响的系统评价.pdf

论病程长短、疗程长短、合并用药与否，SGLT-2抑制剂能更有效降低糖化 95％CI(-0．23，-0．1 结论SGLT-2抑制剂可有效降低2型糖尿病患者的糖化血红蛋白、体 重、血压、甘油三酯，增加高密度脂蛋白胆固醇，有一定增加低密度脂蛋 白胆固醇水平的风险。 关键词SGLT一2抑制剂，2型糖尿病，大血管病变，随机对照试验，系统 评价 万方数据 EFFECTSOFSGLrr_2INHIBITORSON M後CROVASCULARRISK FIACTORSIN TYPE2DIABETES：ASYSTENIATIC REVIEW AB STRACT ToevaluatetheeffectsofSGLT-2inhibitors Objective on macrovascularriskfactorsin 2diabetesmellitusand atheoretical type provide basistoselectantidiabetic drugs． MethodsThe databasesas following National Biomedical Library,China Literature to 1 searchedto Database(CBM)data(deadlineMarch，20 5)were collecttherandomizedcontrolled SGLT-2inhibitors trials(RCTs)of VS placebo ineffectsofSGLT-2inhibitorsonmacrovascular riskfactorswith 2 type diabetesmellitus．Itisassessedthe inaccordancewiththeCochrane quality Handbook5．1andconducted with RevMan5．2software．Wewill meta-analyses outcomemeasuresfor relative compare dichotomous(binary)datausing continuousdata standardizedmean risks(RR)and using 95％confidence