儿童AITD患者血清IL-12、IL-10在疾病不同阶段地观察.docxVIP

天津医科大学硕十研究生论文 hypothyroidisms were higher than that of euthyrodisms and normal subjects． The IL—lO concentratjon of GD(9．52±6．84pg／m1)were lower than that of normal subjects(21．80±5．37pg／ml，P=O．001)．That of the three groups were a11 k料er than normal subjects．That of the diagnosi s subjects lower than these accepting treatment．Among these accepting treatment， that of the hypothyroidisms were lower than that of the euthyrodi sms． 3．The serum IL—12 (209．21±l 18．65pg／ml，P=0．000)were higher than normal subjects．That of the new diagnosis subjects were higher than these accepting treatment and norJI】al subjects． Among these accepting treatment，that of the hyperthyroidisms were higher than the euthyrodi The serum lL一10 concentration of GD subjects(24．19±7．59pg／m1，P =O．037) were higher than normal subjects．That of the new diagnosis subjects were higher than these accepting treatment and normal subjects．Among these accepting treatment， that of the hyperthyroidisms were higher than the euthyrodi sms． 4．Among HT subjects，the serum IL—12 was no significantly correlation with age，TGAb，TMAb，TRAb and TSI，and was negatively significantly correlation with FT4，FT3(r=一0．763，P=O．000 and r=一O．638，P=0．OOO respectively) and positively correlation with sTSH(r=0．514， P= O．000)．The serum IL—10 was significantly correlation wi th age，TGAb，TMAb，TRAb and TSI，and positively significantly correlation wi th FT4，FT3(r=0．452，P=0．000 and r=O．423，P=O．OOO respectively)and 5 天津医科人学硕十研究生论文 hypothyroidisms were higher than the euthyrodisms and normal subjects． The serum IL一10 concentration 10wer than that of normal subjects． The three groups were a1 l lower than normal subjects．The diagnosi s subjects were 10wer than these accepting treatment．Among these accepting treatment， the hypothyroidisms were 10wer than the euthyrodisms． It’s confirⅡled the idea that IL一12 is concerned with disease progress．Contrari 1y，IL一10 has protective effect HT． 3．The serum IL—12 concentration of GD s