材料导论 (50)材料导论.pdf

Hello, everyone. 大家好 As we have discussed, biomaterials undoubtedly improve the health and quality of life for millions of people worldwide. 译文： 如我们已经讨论过的, 生物材料无疑改善了全世界千百万人的健康和生活质量。 Since they are so important, what kinds of materials can be used as biomaterials? We need to know the fundamental requirements. 译文： 既然它们如此重要, 哪些材料可以作为生物材料使用呢？我们需要知道生物材 料的基本要求。 All biomaterials meet certain requirements before they can be qualified for use in medical applications. 译文： 所有生物材料都符合一定的要求, 才能在医疗应用中使用。 Firstly, we need to clarify that the requirements are highly dependent on a particular application. In other words, the requirements may be considerably different for different applications. 译文： 首先, 我们需要澄清, 这些要求高度依赖于特定的应用。换言之, 对于不同的应 用, 要求可能会有很大不同。 Let’s see the example of poly (lactide-co-glycolide acid) (PLGA). 译文： 我们看一下聚丙交酯-乙交酯酸 (PLGA) 的例子。 PLGA is a biodegradable copolymer and can be processed into any shape and size. 译文： PLGA 是一种可生物降解的共聚物, 可以被加工成任何形状和尺寸。 They could be used as both drug carriers and tissue engineering scaffolds, which has got Food and Drug Administration (FDA) approval for clinical use. 译文： 它们可被用作药物载体和组织工程支架, 并已获得食品和药物管理局 (FDA) 的 临床使用批准。有缘学习更多驾卫星ygd3076 Microparticles, nanoparticles and nanofbers of PLGA have been developed for drug delivery. PLGA nanoparticles could be formed through emulsion-solvent evaporation method and drug will be encapsulated in the nanoparticles. 译文： PLGA 的微粒、纳米颗粒和纳米纤维已被成功制备, 用于药物的输送。PLGA 纳 米微粒可以通过乳液-溶剂蒸发法可以形成, 同时将药物封装在纳米颗粒中。 For the application as drug carriers, PLGA matrix is first required to carry sufficient amount of drug. For controlled drug release, the matrix need to provide proper binding affinity with drug and allow homogeneous drug distribution in the matrix. The matrix should also keep the structure and activity of d