《基础医学各论II》课件：内分泌系统病理学.pdf

Thyroid Disease Pathology Department, Zhejiang University School of Medicine, 马丽琴，maliqin198@zju.edu.cn cartilage thyroidea thyroid simple cuboidal epithelium colloid Normal thyroid seen microscopically consists of follicles lined by a an epithelium and filled with colloid. This immunoperoxidase stain with antibody to calcitonin （降血钙素）identifies the C cells immunofluorescence test positive for anti- microsomal antibody(抗微粒体抗体) immunofluorescence positivity for anti- thyroglobulin( 甲状腺球蛋白)antibody Thyroiditis Goiter Thyroid tumor Thyroiditis Type Acute , bacterial infection Subacute , viral infection Chronic ,(chronic lymphocytic thyroiditis;CLT), autoimmune disease Subacute thyroiditis: viral infection Granulomatous inflammation， granulomatous thyroiditis/giant cell thyroiditis 20-50-year old female fever, thyromegaly , tenderness, Gross : gray, firm, adhesions, necrosis foreign-body giant cell reaction Chronic thyroiditis: Chronic lymphocytic thyroiditis;CLT Fibrous thyroiditis Chronic thyroiditis: Chronic lymphocytic thyroiditis (Hashimoto’s thyroiditis 桥本病): autoimmune disease，antibody(+), Gross: thyromegaly, nodosity, grayish-white, hypofunction, Histologic: thyroid follice atrophy, destroy , lymphocyte, plasmocyte, fibroplasia Chronic lymphocytic thyroiditis thyroid follice atrophy,destroy ,lymphocyte, eosinophils, plasmocyte, fibroplasia Fibrous thyroiditis (Riedel goiter, chronic woody thyroiditis 慢性木样甲状腺炎): rare, hoarse voice, dysphagia, dyspneic respiration, wood-like thyroid follice atrophy, fibroplasia, hyalinosis, Fibrous thyroiditis Fibroplasia, hyalinos, lymphocyte Goiter Conception: Goiter is a group o