《基础医学各论II》课件：消化系统病理学.pdf

Diseases of Digestive System Pathology Department, Zhejiang University School of Medicine, 马丽琴，maliqin198@zju.edu.cn Oesophagus liver Stomach Pancreas small intestine large intestine sinus ventriculi Structure of Digestive tube mucous layer (粘膜层) submucosa (粘膜下层) muscular layer (肌层) serous membrane (浆膜层) Normal gastric mucosa Normal gastric mucosa Normal gastric mucosa Diseases of Digestive System  Gastritis (acute, chronic )  Peptic ulcer  Appendicitis  Viral hepatitis  Cirrhosis of liver  Tumor Acute gastritis Early changes : mucosal congestion and edema. Severe changes: mucosal erosions and hemorrhage. Inflammatory infiltration Clinical course Asympatomatic Epigastric pain , nausea , vomiting , hematemesis and potentially fatal blood loss. Chronic gastritis Chronic Superficial gastritis, CSG Chronic Atrophic gastritis, CAG Verrucosa gastritis Hypertrophic gastritis Chronic Superficial gastritis, CSG Mucosal congestion and edema. Chronic inflammatory cell infiltration (mainly lymphocytes and plasmacytes) in superficial mucosa. Glands keep intact Chronic superficial gastritis Chronic Atrophic gastritis, CAG  Glandular atrophy , decrease or loss of specialized secretory cell ( parietarl cells , chief cells )  Chronic inflammatory cell infiltration and H.pylori-induced proliferation of lymphoid tissue within the gastric mucosa.  Intestinal and pseudo