不同剂量碘化钾对大鼠血液抗氧化能力影响.docVIP

不同剂量碘化钾对大鼠血液抗氧化能力影响 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：不同剂量碘化钾对大鼠血液抗氧化能力影响 1 1 材料与方法 2 2 结果 3 3 讨论 4 文2：赖氨酸对大鼠骨质疏松的防治作用 5 1 材料与方法 6 2 结果 7 3 讨论 8 参考文摘引言： 9 原创性声明（模板） 11 文章致谢（模板） 11 正文 不同剂量碘化钾对大鼠血液抗氧化能力影响 文1：不同剂量碘化钾对大鼠血液抗氧化能力影响 Effect of different dosage potassium iodide on anti-oxidative capability of rats blood Abstract： Objective To study the effect of different dosage KI on the anti-oxidative capability of The rats were divided into 6 groups and given by different dosage of KI,which were low iodide (LI),normal iodide (NI),5 fold high iodide (5HI),10 fold high iodide (10HI),50 fold high iodide (50HI) and 100 fold high iodide (100HI).Three,6 and 12 months later,the rats were sacrificed and blood glutathione peroxidase (GPx) activity,superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were After treatment for 3 and 6 months,the GPx activity in LI group was markedly lower than that in NI ,after 6 months for low iodine intake,the MDA content in LI group was higher than that in NI GPx activity in 100HI group was lower than that in NI group after administration for 3 months,but no difference between these two groups after treatment for 6 and 12 months,no difference was found in the GPx activity of NI group and those of 5HI,10HI and 50HI was no difference in SOD activity and MDA content among NI group and 4 high iodide Low iodide intake would damage the anti-oxidative capability of blood in normal had a strong anti-oxidative ability and compeative capabilities to compete with high iodide intake. Key words： potassium iodide(KI);anti-oxidative capacity;blood 碘是合成甲状腺激素(TH)的必需微量元素，低碘或高碘都将导致甲状腺疾病。地方性甲状腺肿、Graves病、桥本氏病和甲状腺癌等甲状腺疾病发生和 发展 的重要机制之一是自由基(FR)的毒性作用〔1〕。有学者认为FR损伤作用也是碘导致的甲状腺疾病的发病机制之一〔2〕。为深入研究FR在碘致疾病中的作用，本实验观察了不同剂量碘化钾(KI)对血液抗氧化能力的影响。 1 材料与方法 11 实验动物与分组 选用断乳后1个月，体重120～140g的健康Wistar大鼠270只，随机分为6组：低碘组(LI组)、适碘组(NI组)、5倍高碘组(5HI组)、10倍高碘组(10HI组)、50倍高碘组(50HI组)、100倍高碘组(100HI组)，每组45只。喂养3，6，12个月后，股动脉取血处死大鼠。此外，12个月时LI组鼠死亡，故未取