西那卡塞对血液透析患者继发性甲状旁腺功能亢进的疗效观察.docxVIP

西那卡塞对血液透析患者继发性甲状旁腺功能亢进的疗效观察 　　【摘要】目的探索西那卡塞治疗血液透析患者继发性甲状旁腺功能亢进的效果。方法50例血液透析继发性甲状旁腺功能亢进患者，根据随机数字表法分为观察组与对照组，各25例。对照组给予骨化三醇治疗，观察组在对照组治疗基础上给予西那卡塞治疗。比较两组治疗效果及治疗前后血清钙、血清磷、全段甲状旁腺激素（ipth）水平的差异。结果观察组患者治疗总有效率为100.0%，明显高于对照组的84.0%，差异具有统计学意义（p0.05）。治疗前，两组患者血清钙、血清磷、ipth水平比较差异无统计学意义（p0.05）;治疗后，两组血清钙水平均明显升高，血清磷、ipth水平明显降低，差异具有统计学意义（p0.05）;治疗后，观察组患者血清钙水平明显高于对照组，血清磷和ipth水平明显低于对照组，差异均具有统计学意义（p0.05）。结论西那卡塞在血液透析后继发性甲状旁腺功能亢进治疗中疗效显著，可改善患者甲状旁腺激素（pth）分泌，值得推广。 　　【关键词】西那卡塞;骨化三醇;血液透析;继发性甲状旁腺功能亢进 　　doi：10.14163/ki.11-5547/r.2019.11.038 　　【abstract】objectivetoinvestigatetheeffectofsinacaseronsecondaryhyperparathyroidisminhemodialysispatients.methodsatotalof50hemodialysispatientswithsecondaryhyperparathyroidismweredividedintoobservationgroupandcontrolgroupaccordingtorandomnumbertablemethod，with25casesineachgroup.thecontrolgroupwastreatedwithcalcitriol，parisonweremadeontreatmenteffect，differencesofserumcalcium，phosphorusandimmunoreactiveparathyroidhormone（ipth）levelsbeforeandaftertreatmentintwogroups.resultstheobservationgrouphadobviouslyhighertotaltreatmenteffectiverateas100.0%than84.0%inthecontrolgroup，andthedifferencewasstatisticallysignificant（p0.05）.beforetreatment，bothgroupshadnostatisticallysignificantdifferenceinserumcalcium，serumphosphorusandipthlevel（p0.05）.aftertreatment，bothgroupshadobviouslyhigherserumcalcium，andobviouslylowerserumphosphorusandipthlevel.theirdifferencewasstatisticallysignificant（p0.05）.aftertreatment，theobservationgrouphadobviouslyhigherserumcalciumlevelthanthecontrolgroup，andobviouslylowerserumphosphorusandipthlevelthanthecontrolgroup.theirdifferencewasstatisticallysignificant（p0.05）.conclusionsinacasershowssignificantefficacyinthetreatmentofsecondaryhyperparathyroidismafterhemodialysis.，anditcanimprovethesecretionofparathyroidhormone（pth）.itisworthpopularizing. 　　【keywords】sinacaser;calcitriol;hemodialysis;secondaryhyperparathyroidism 　　血液透析是治療多种疾病的有效方法，尤其是慢性肾脏疾病终末期的患者，需长期血液透析治疗，长期血液透析患者可引起继发性甲状旁腺功能亢进，进而增加骨病、软组织、心血管钙化、心血管疾病的发病率[1]。西那卡塞是拟钙剂的新